慢性阻塞性肺疾病患者脑白质微结构变化的初步研究
发布时间：2018-08-26 18:09
【摘要】：目的:采用基于白质纤维束空间统计分析(tract based spatial statistics,TBSS)的方法研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者全脑白质纤维束微观结构变化。方法:选取30例稳定期COPD患者和30例性别、年龄及教育程度匹配的健康志愿者(对照组),应用3.0 T磁共振进行全脑DTI(diffusion tensor imaging)序列扫描。采用TBSS方法对2组被试全脑白质纤维束的部分各向异性指数(fractional anisotropy,FA)、平均弥散率(mean diffusivity,MD)进行基于体素的全脑非参数统计学比较。结果:与正常对照组相比,COPD组的胼胝体、双侧丘脑前辐射、皮质脊髓束、左侧额枕下束、左侧上纵束FA值明显下降(P0.05,TFCE校正);胼胝体、双侧额枕下束、右侧丘脑前辐射、左侧钩束MD值明显升高(P0.05,TFCE校正)。结论:相对于正常对照组,COPD患者大脑白质纤维束出现多发微观损伤,其DTI多参数改变提示与认知损伤、情绪调节相关的脑白质纤维髓鞘结构完整性发生退变。
[Abstract]:Aim: to study the microstructural changes of white matter bundle in patients with chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) based on spatial statistical analysis of white matter bundle (tract based spatial statistics,TBSS). Methods: 30 patients with stable COPD and 30 healthy volunteers with matched sex, age and education level (control group) were examined with 3. 0 T Mr DTI (diffusion tensor imaging) sequence. The partial anisotropy index (fractional anisotropy,FA) and the mean diffusion rate (mean diffusivity,MD) of the white matter fiber bundles in the whole brain of the two groups were compared with the voxel based nonparametric statistics by TBSS method. Results: the FA values of corpus callosum, bilateral anterior thalamic radiation, corticospinal tract, left frontal suboccipital tract, left superior longitudinal tract, corpus callosum, bilateral frontal suboccipital tract and right thalamus were significantly decreased in COPD group compared with normal control group (P 0.05). The MD value of the left hook bundle was significantly increased (P 0.05). Conclusion: compared with the normal control group, there are multiple microcosmic lesions in the white matter fiber bundle of the brain, and the changes of multiple parameters of DTI suggest that the myelin structure integrity of the white matter fiber is related to cognitive impairment and emotion regulation.
【作者单位】： 重庆医科大学神经科学中心;陆军军医大学生物医学工程学院医学图像学教研室;陆军军医大学新桥医院核医学科;陆军军医大学新桥医院肿瘤科;陆军军医大学新桥医院放射科;
【基金】：重庆市渝中区科委科技资助项目(编号:20130132)
【分类号】：R563.9;R747.9
，
本文编号：2205738
[Abstract]:Aim: to study the microstructural changes of white matter bundle in patients with chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) based on spatial statistical analysis of white matter bundle (tract based spatial statistics,TBSS). Methods: 30 patients with stable COPD and 30 healthy volunteers with matched sex, age and education level (control group) were examined with 3. 0 T Mr DTI (diffusion tensor imaging) sequence. The partial anisotropy index (fractional anisotropy,FA) and the mean diffusion rate (mean diffusivity,MD) of the white matter fiber bundles in the whole brain of the two groups were compared with the voxel based nonparametric statistics by TBSS method. Results: the FA values of corpus callosum, bilateral anterior thalamic radiation, corticospinal tract, left frontal suboccipital tract, left superior longitudinal tract, corpus callosum, bilateral frontal suboccipital tract and right thalamus were significantly decreased in COPD group compared with normal control group (P 0.05). The MD value of the left hook bundle was significantly increased (P 0.05). Conclusion: compared with the normal control group, there are multiple microcosmic lesions in the white matter fiber bundle of the brain, and the changes of multiple parameters of DTI suggest that the myelin structure integrity of the white matter fiber is related to cognitive impairment and emotion regulation.
【作者单位】： 重庆医科大学神经科学中心;陆军军医大学生物医学工程学院医学图像学教研室;陆军军医大学新桥医院核医学科;陆军军医大学新桥医院肿瘤科;陆军军医大学新桥医院放射科;
【基金】：重庆市渝中区科委科技资助项目(编号:20130132)
【分类号】：R563.9;R747.9
，
本文编号：2205738
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