复合乳酸菌治疗不同程度肺功能损害的中老年慢性阻塞性肺疾病急性加重的疗效

发布时间：2018-09-04 17:27

【摘要】：目的探讨复合乳酸菌治疗不同程度肺功能损害的中老年慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法 20例重度和28例极重度肺功能损害的中老年AECOPD患者,分别接受常规治疗〔重度13例(对照组1),极重度14例(对照组2)〕和常规+复合乳酸菌治疗〔重度7例(治疗组1),极重度14例(治疗组2)〕。记录各组住院天数、治疗前、治疗后7 d血气、呼吸困难评分、肺功能、炎症指标、纳差评分、真菌感染人数、死亡人数、呼吸频率、复合乳酸菌不良反应。结果治疗后,治疗组2纳差评分显著低于对照组2(P0.05);治疗组1氧合指数显著高于对照组1(P0.05);与各对照组比较,各治疗组其余观察指标无显著差异(P0.05)。各治疗组未见皮疹、腹泻等。结论对于中老年患者,复合乳酸菌有改善极重度AECOPD患者食欲和氧合的作用,安全性好。
[Abstract]:Objective to investigate the efficacy of combined lactic acid bacteria (Lactic acid bacteria) in the treatment of chronic obstructive pulmonary disease (AECOPD) in middle and old aged patients with different degree of pulmonary function damage. Methods Twenty middle-aged and aged AECOPD patients with severe pulmonary dysfunction and 28 patients with extremely severe pulmonary dysfunction were studied. Routine treatment (severe 13 cases (control group 1), extremely severe 14 cases (control group 2), routine combined lactobacillus therapy (severe 7 cases (treatment group 1), extremely severe 14 cases (treatment group 2).) The days of hospitalization, blood gas, dyspnea score, pulmonary function, inflammation index, anorexia score, number of fungal infection, number of death, respiratory frequency and adverse reaction of compound lactic acid bacteria were recorded before and 7 days after treatment. Results after treatment, the scores of anorexia in the treatment group were significantly lower than those in the control group (P0.05); the oxygenation index in the treatment group was significantly higher than that in the control group (P0.05); compared with each control group, there was no significant difference in other observed indexes in each treatment group (P0.05). No rash, diarrhea and so on were found in each treatment group. Conclusion compound lactic acid bacteria can improve appetite and oxygenation in patients with very severe AECOPD.
【作者单位】：柳州市柳铁中心医院呼吸内科;
【基金】：广西卫生厅自筹经费课题项目(Z2011235) 柳州市科学研究与技术开发计划课题资助项目(2013J030413)
【分类号】：R563.9

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