注射用胸腺法新对社区获得性重症肺炎老年患者体内T淋巴细胞亚群及血清免疫蛋白的影响

发布时间：2018-09-05 08:44

【摘要】：目的观察胸腺法新对社区获得性重症肺炎老年患者体内T淋巴细胞亚群和体液免疫球蛋白水平的影响。方法将61例ICU社区获得性重症肺炎老年患者随机分为两组,对照组入院后予经口气管插管接呼吸机辅助通气并先按经验予抗感染等对症支持治疗,然后根据细菌培养结果调整抗生素使用;观察组在常规治疗基础上使用胸腺法新1.6 mg皮下注射,2次/d,治疗1周。比较两组患者体内T淋巴细胞亚群、免疫球蛋白和临床转归。结果观察组患者体内CD4+T淋巴细胞亚群比例高于对照组,差异有统计学意义(P0.05);两组患者血清补体C3、C4、IgG、IgM、IgA免疫球蛋白水平及临床疗效比较,差异无统计学意义(P0.05)。结论胸腺法新可以提高体内CD4+T淋巴细胞亚群比例。
[Abstract]:Objective to observe the effect of thymus on T lymphocyte subsets and humoral immunoglobulin levels in elderly patients with community acquired severe pneumonia. Methods Sixty-one elderly patients with ICU community-acquired severe pneumonia were randomly divided into two groups. The control group was treated with tracheal intubation and ventilator assisted ventilation after admission. Then the antibiotics were adjusted according to the results of bacterial culture, and the observation group was treated with thymus 1. 6 mg subcutaneous injection twice a day for 1 week. T lymphocyte subsets, immunoglobulin and clinical outcome were compared between the two groups. Results the percentage of CD4 T lymphocyte subsets in patients in the observation group was higher than that in the control group (P0.05), and there was no significant difference between the two groups (P0.05). Conclusion thymus assay can increase the proportion of CD4 T lymphocyte subsets in vivo.
【作者单位】：广东省汕头市中心医院ICU;广东省汕头市中心医院感染科;广东省汕头市中心医院呼吸科;
【分类号】：R563.1

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