老年糖尿病患者肺部感染与免疫功能相关性研究

发布时间：2018-09-05 14:58

【摘要】：目的探讨老年糖尿病患者肺部感染与体内免疫功能的相关性。方法选取2014年6月-2016年5月48例老年糖尿病合并肺部感染患者作为感染组,48例无肺部感染的老年糖尿病患者作为未感染组,比较两组患者免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及CD_3~+、CD_4~+、CD_8~+ 、CD_4~+/CD_8~+ ,并探讨老年糖尿病合并肺部感染患者C-反应蛋白(CRP)与IgG、IgA、IgM及CD_3~+、CD_4~+、CD_8~+ 、CD_4~+/CD_8~+ 的相关性。结果感染组患者IgG为(11.62±3.11)g/L,显著低于未感染组的(13.93±3.20)g/L,两组差异有统计学意义(P0.01);两组患者IgA、IgM比较,差异无统计学意义;感染组患者CD_3~+、CD_4~+、CD_4~+/CD_8~+ 分别为(61.33±8.90)%、(33.42±7.29)%、(1.13±0.28)%,显著低于未感染组的(67.43±8.76)%、(37.31±7.26)%、(1.33±0.31)%,两组差异有统计学意义(P0.05);两组患者CD_8~+ 比较差异无统计学意义;CRP与IgG、CD_3~+、CD_4~+、CD_4~+/CD_8~+ 均呈显著负相关(P0.05)。结论老年糖尿病患者肺部感染与免疫功能密切相关,且合并肺部感染的老年糖尿病患者体液免疫与细胞免疫功能均受损,受损程度随着肺部感染病情的加重而加重。
[Abstract]:Objective to investigate the correlation between pulmonary infection and immune function in elderly diabetic patients. Methods from June 2014 to May 2016, 48 elderly diabetic patients with pulmonary infection were selected as infection group and 48 elderly diabetic patients without pulmonary infection as uninfected group. The immunoglobulin G (IgG), immunoglobulin A (G (IgG),) immunoglobulin A (IgA),) immunoglobulin M (IgM) (IGM) and CD_3~ CD4 (+ CD4) were compared between the two groups. The correlation between (CRP) and IgG,IgA,IgM and CD_3~ CD4 / SECT CD4 / CD8 was also discussed in the elderly patients with diabetes mellitus complicated with pulmonary infection. Results the IgG of the infected group was (11.62 卤3.11) g / L, which was significantly lower than that of the non-infected group (13.93 卤3.20) g / L, the difference was statistically significant (P0.01), there was no significant difference in IgA,IgM between the two groups. In the infected group, the levels of CD_3~ / CD4- / CDS were (61.33 卤8.90), (33.42 卤7.29), (1.13 卤0.28), significantly lower than those in the non-infected group (67.43 卤8.76), (37.31 卤7.26), (1.33 卤0.31), respectively (P0.05). There was no significant difference in CD_8~ between the two groups (P0.05). Conclusion Pulmonary infection is closely related to immune function in elderly diabetic patients, and both humoral and cellular immune functions of elderly diabetic patients with pulmonary infection are impaired, and the degree of damage is aggravated with the exacerbation of pulmonary infection.
【作者单位】：苏州大学附属第二医院中医科;苏州大学附属第二医院感染科;
【分类号】：R563.1;R587.2

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