肺泡灌洗液含铁血黄素细胞对常见肺疾病的诊断意义
发布时间：2018-09-06 19:51
【摘要】：肺组织内出血时从血管中溢出的红细胞被巨噬细胞吞噬，并在其溶酶体内降解，，形成光镜下可见的棕黄色颗粒，即为含铁血黄素。这种巨噬细胞称为含铁血黄素细胞(hemosiderin-ladenmacrophage,HLM)。通常用普鲁士蓝染色涂片检测。为了鉴定支气管肺泡灌洗液（bronchoalveolar lavage fluid，BALF）内HLM对于肺部常见疾病诊断的指导意义，我们对2012年4月到10月期间在上海长海医院进行支气管肺泡灌洗术检查的102例住院患者进行了回顾性的调查研究。将这些患者根据疾病诊断及各项临床及生物学指标进行分组，同时将2012年4月到10月进行BALF检查的12例体检正常者作为对照组。对送检的BALF进行涂片、普鲁士蓝法染色后，由两名经过专业培训的人员进行HLM指数的计数。整理实验组与对照组数据，最后用SPSS软件进行HLM相关的统计分析。主要结果：（1）BALF中HLM与2项指标密切相关：肾功能不全（Cr177μmoI/L）；吸烟（10包年）。（2）咯血患者的HLM较未出现咯血症状的患者多。（3）HLM在肺部真菌感染（尤其是侵袭性肺曲霉菌病）比肺部细菌、结核或病毒感染更易出现。（4）肺脓肿、支气管扩张患者BALF的HLM指数较高。总的来说，BALF中HLM对肺部疾病的诊断有一定指导作用。
[Abstract]:The red blood cells which overflow from the blood vessels during the hemorrhage of lung tissue were swallowed by macrophages and degraded in their lysosomes to form brown granules visible under light microscope, that is, hemosiderin. These macrophages are called hemosiderin cells (hemosiderin-ladenmacrophage,HLM). Prussian blue stains are usually used for detection. To identify the guiding significance of HLM in bronchoalveolar lavage fluid (bronchoalveolar lavage fluid,BALF) for the diagnosis of common lung diseases. A retrospective study was conducted on 102 inpatients who underwent bronchoalveolar lavage in Changhai Hospital from April to October 2012. These patients were divided into two groups according to disease diagnosis and clinical and biological indexes, and 12 normal persons who underwent BALF from April to October 2012 were used as control group. The BALF was smeared and stained by Prussian blue, and the HLM index was counted by two trained personnel. The data of the experimental group and the control group were collected. Finally, the HLM related statistical analysis was carried out with SPSS software. The main results were as follows: (1) HLM in BALF was closely related to two indexes: Cr177 渭 moI/L, HLM in patients with hemoptysis (10 packets of). (2) was higher than that in patients without hemoptysis. (3) HLM was more common in pulmonary fungal infection than in invasive pulmonary aspergillosis. Tuberculosis or viral infection is more likely to occur. (4) Pulmonary abscess, bronchiectasis patients with higher HLM index. In general, HLM in BALF has a guiding role in the diagnosis of pulmonary diseases.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563
本文编号：2227371
[Abstract]:The red blood cells which overflow from the blood vessels during the hemorrhage of lung tissue were swallowed by macrophages and degraded in their lysosomes to form brown granules visible under light microscope, that is, hemosiderin. These macrophages are called hemosiderin cells (hemosiderin-ladenmacrophage,HLM). Prussian blue stains are usually used for detection. To identify the guiding significance of HLM in bronchoalveolar lavage fluid (bronchoalveolar lavage fluid,BALF) for the diagnosis of common lung diseases. A retrospective study was conducted on 102 inpatients who underwent bronchoalveolar lavage in Changhai Hospital from April to October 2012. These patients were divided into two groups according to disease diagnosis and clinical and biological indexes, and 12 normal persons who underwent BALF from April to October 2012 were used as control group. The BALF was smeared and stained by Prussian blue, and the HLM index was counted by two trained personnel. The data of the experimental group and the control group were collected. Finally, the HLM related statistical analysis was carried out with SPSS software. The main results were as follows: (1) HLM in BALF was closely related to two indexes: Cr177 渭 moI/L, HLM in patients with hemoptysis (10 packets of). (2) was higher than that in patients without hemoptysis. (3) HLM was more common in pulmonary fungal infection than in invasive pulmonary aspergillosis. Tuberculosis or viral infection is more likely to occur. (4) Pulmonary abscess, bronchiectasis patients with higher HLM index. In general, HLM in BALF has a guiding role in the diagnosis of pulmonary diseases.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563
【参考文献】
相关期刊论文 前2条
1 沈敏;王玉;曾学军;范洪伟;许文兵;唐福林;;系统性红斑狼疮合并弥漫肺泡出血病例分析[J];基础医学与临床;2007年04期
2 覃肇源,丘小汕,沈振宇,柯志勇;特发性肺含铁血黄素沉着症的诊断和治疗[J];实用儿科临床杂志;2005年05期
本文编号：2227371
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