慢性阻塞性肺疾病患者ADAMTS-13的表达及与血栓前状态和炎症反应的关系

发布时间：2018-09-08 18:16

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)患者ADAMTS-13的表达及与血栓前状态和炎症反应的关系。方法收集该院2013年1月至2014年12月收治的140例COPD患者的临床资料,其中70例急性加重期患者为加重组,70例稳定期患者为稳定组;另选取140例同期在我院行健康体检者作为对照组,其中70例吸烟者作为吸烟对照组,70例非吸烟者作为非吸烟对照组。比较四组研究者一般资料、血生化指标包括纤维蛋白原、C反应蛋白(CRP)、白细胞介素(IL)-6及血浆ADAMTS-13和v WF的水平。结果四组研究者吸烟指数比较差异具有统计学意义(P0.05),且在加重组、稳定组及吸烟对照组呈逐渐下降趋势;各组间肺功能指标FEV1%、FEV1以及FEV1/FVC%比较具有统计学差异(P0.05),且在加重组、稳定组、吸烟对照组及非吸烟对照组表现为递增趋势。四组研究者纤维蛋白原、CRP及IL-6比较具有统计学差异(P0.05),且在加重组、稳定组、吸烟对照组及非吸烟对照组均表现为下降趋势。四组研究者血浆v WF及ADAMTS-13比较具有统计学差异(P0.05),且v WF在加重组、稳定组、吸烟对照组及非吸烟对照组表现为下降趋势,而ADAMTS-13在四组间表现为上升趋势。多重线性回归分析发现,COPD患者血浆ADAMTS-13水平与纤维蛋白原、CRP、IL-6及血浆v WF表现为明显负相关性(P0.05)。结论 COPD患者长期的炎症反应可能是造成其血浆ADAMTS-13水平下降的重要原因之一,而ADAMTS-13水平下降可造成v WF水平升高加重患者的血检前状态。
[Abstract]:Objective to investigate the expression of ADAMTS-13 in patients with chronic obstructive pulmonary disease (COPD) and its relationship with prethrombotic state and inflammatory reaction. Methods the clinical data of 140 patients with COPD admitted to our hospital from January 2013 to December 2014 were collected. 70 patients with acute exacerbation were treated with recombination and 70 stable patients as stable group. In addition, 140 healthy persons in our hospital were selected as the control group, 70 smokers as the smoking control group and 70 non-smokers as the non-smoking control group. Compared with the general data of the four groups, the blood biochemical indexes included the levels of fibrinogen C-reactive protein (CRP), interleukin (IL) -6 and plasma ADAMTS-13 and v WF. Results the smoking index of the four groups was significantly different (P0.05), and in the recombination, the stable group and the smoking control group showed a decreasing trend; the pulmonary function indexes FEV1%,FEV1 and FEV1/FVC% were significantly different among the four groups (P0.05), and were in the addition of recombination. Stable group, smoking control group and non-smoking control group showed an increasing trend. Fibrinogen CRP and IL-6 were significantly different among the four groups (P0.05), and decreased in the recombination, stabilization, smoking control and non-smoking control groups. There were significant differences in plasma v WF and ADAMTS-13 among the four groups (P0.05), and v WF in the recombination group, stable group, smoking control group and non-smoking control group showed a downward trend, while ADAMTS-13 showed an upward trend among the four groups. Multiple linear regression analysis showed that there was a negative correlation between plasma ADAMTS-13 level and fibrinogen CRPU IL-6 and plasma v WF (P0.05). Conclusion the long-term inflammatory reaction in patients with COPD may be one of the important reasons for the decrease of plasma ADAMTS-13 level, and the decrease of ADAMTS-13 level may lead to the increase of v WF level.
【作者单位】：潍坊医学院附属医院呼吸内科;
【分类号】：R563.9

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