COPD稳定期患者血清IL-6、IL-18、CC16水平与肺功能及CAT评分的关系

发布时间：2018-09-10 16:55

【摘要】：目的:探讨慢性阻塞性肺疾病(COPD)稳定期患者血清IL-6、IL-18、人克拉拉细胞分泌蛋白(CC16)水平变化与肺功能及慢阻肺评估测试(CAT)评分的关系。方法 :检测COPD组200例和对照组100例血清IL-6、IL-18、CC16浓度,并完成肺功能检查和CAT评分问卷。在COPD组患者中,将肺功能为Ⅰ~Ⅱ级者作为A亚组,Ⅲ~Ⅳ级者作为B亚组;根据COPD组患者的CAT评分,将0≤CAT分≤20者作为C亚组,21≤CAT分≤40者作为D亚组。结果:(1)与对照组相比,COPD组血清IL-6、IL-18水平升高,而CC16水平降低(均P0.01)。(2)与A亚组比较,B亚组血清IL-6、IL-18水平升高,CC16水平降低(均P0.01)。(3)与C亚组相比,D亚组血清IL-6、IL-18水平升高(P0.01),CC16水平降低(P=0.08)。(4)相关性分析:COPD稳定期患者FEV1%与血清IL-6、IL-18水平呈负相关(r=-0.765,r=-0.721,P0.01),而与血清CC16水平呈正相关(r=0.397,P0.01)。COPD患者血清CC16水平与血清IL-6、IL-18浓度均呈负相关性(r=-0.221,r=-0.279,P0.01),CAT评分与血清IL-6、IL-18浓度呈正相关(r=0.500,r=0.533,P0.01)。结论 :COPD稳定期患者血清IL-6、IL-18水平升高,CC16水平降低,可能参与了COPD肺功能损伤,并可能与COPD患者生存质量下降有关。
[Abstract]:Aim: to investigate the relationship between the level of serum IL-6,IL-18, human Clara cell secretory protein (CC16) and pulmonary function and (CAT) score of chronic obstructive pulmonary disease (COPD) in patients with chronic obstructive pulmonary disease (COPD). Methods: the concentration of serum IL-6,IL-18,CC16 was measured in 200 cases of COPD group and 100 cases of control group. Pulmonary function test and CAT score questionnaire were completed. In the COPD group, the patients with grade 鈪，

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