重症肺部感染患者不同激素辅助治疗的临床研究

发布时间：2018-09-11 09:20

【摘要】：目的探讨地塞米松、氢化可的松、甲泼尼龙辅助治疗重症肺部感染的临床效果,以期提高临床治疗水平。方法随机选取2011年2月-2013年4月99例严重外伤后重症肺部感染患者为研究对象,分成3组,每组各33例,均在对症、抗感染等治疗的基础上分别予以地塞米松、氢化可的松、甲泼尼龙辅助治疗,观察治疗后临床效果差异性,数据采用SPSS13.0软件进行分析。结果地塞米松组的治愈率为27.27%,总有效率为69.69%;氢化可的松组的治愈率为30.31%,总有效率为75.76%,甲泼尼龙组的治愈率为69.7%,总有效率为93.94%;地塞米松组与氢化可的松组比较差异无统计学意义,甲泼尼龙组与其他两组比较差异有统计学意义(P0.05);地塞米松组与氢化可的松组咳嗽、咳痰消失时间等症状改善以及第一秒最大呼气量和最大呼气流速峰值等肺功能比较差异无统计学意义,甲泼尼龙组与以上两组在各项指标中比较则差异均有统计学意义(P0.05)。结论甲泼尼龙辅助治疗并发重症肺部感染临床效果较满意,但是要严格掌握适应证。
[Abstract]:Objective To investigate the clinical effect of dexamethasone, hydrocortisone and methylprednisolone in adjuvant treatment of severe pulmonary infection in order to improve the level of clinical treatment.Methods 99 patients with severe pulmonary infection after severe trauma from February 2011 to April 2013 were randomly selected and divided into three groups, each group of 33 cases, all on the basis of symptomatic treatment and anti-infection treatment. Results The cure rate of dexamethasone group was 27.27%, the total effective rate was 69.69%; the cure rate of hydrocortisone group was 30.31%, the total effective rate was 75.76%, and the cure rate of methylprednisolone group was 75.76%. The total effective rate was 93.94%. There was no significant difference between dexamethasone group and hydrocortisone group. There was significant difference between methylprednisolone group and the other two groups (P There was no significant difference in lung function between the two groups, but there was significant difference in each index between the methylprednisolone group and the above two groups (P 0.05).
【作者单位】：龙泉市人民医院呼吸内科;
【基金】：浙江省卫生厅科技基金资助项目(ZW-2009B-1014)
【分类号】：R563.1

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