盐酸左氧氟沙星治疗急性肺部感染的临床效果研究

发布时间：2018-09-11 20:36

【摘要】：目的探讨针对急性肺部细菌性感染患者使用盐酸左氧氟沙星序贯治疗的临床效果及不良反应。方法选取2012年9月-2013年12月医院急性肺部细菌性感染患者160例,对其送检标本进行病原菌检测,菌种鉴定采用法国生物梅里埃公司的VITEK-60全自动细菌分析仪,药物敏感试验采用方法是K-B纸片扩散法;按数学随机方法分为普通组和治疗组,各80例,普通组使用盐酸左氧氟沙星注射液治疗,治疗组使用盐酸左氧氟沙星注射液及胶囊序贯方案治疗,对比两组治疗效果及不良反应。结果 160例感染患者培养分离出186株病原菌,革兰阴性菌133株占71.51%,革兰阳性菌53株占28.49%,肺炎克雷伯菌、铜绿假单胞菌、肺炎链球菌、不动杆菌属、金黄色葡萄球菌为主要菌种;治疗有效率普通组患者为92.50%、治疗组患者为92.50%,对比差异无统计学意义;不良反应发生率普通组患者为3.75%、治疗组患者为2.50%,两组不良反应发生率对比差异无统计学意义。结论针对急性肺部细菌性感染患者使用盐酸左氧氟沙星注射液及胶囊序贯治疗的临床效果与仅使用盐酸左氧氟沙星注射液治疗的效果相近,序贯治疗经济性较好且安全性更高,值得临床推广应用。
[Abstract]:Objective to investigate the clinical effects and adverse reactions of levofloxacin hydrochloride (levofloxacin hydrochloride) in patients with acute pulmonary bacterial infection. Methods A total of 160 patients with acute pulmonary bacterial infection from September 2012 to December 2013 were selected and tested for pathogenic bacteria. The bacteria were identified by VITEK-60 automatic bacteria analyzer of French Bio-Meridier Company. The drug sensitivity test was conducted by K-B disk diffusion method, and was randomly divided into two groups, 80 cases in each group, and 80 cases in each group. The common group was treated with levofloxacin hydrochloride injection. The treatment group was treated with levofloxacin hydrochloride injection and capsule sequential regimen. Results 186 pathogenic bacteria were isolated from 160 infected patients, 133 Gram-negative bacteria accounted for 71.51 and 53 Gram-positive bacteria accounted for 28.49.The Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus pneumoniae, Acinetobacter spp., Staphylococcus aureus were the main strains. The effective rate of treatment was 92.50 in the general group and 92.50 in the treatment group. The incidence of adverse reactions was 3.75 in the common group and 2.50 in the treatment group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion the clinical effect of levofloxacin hydrochloride injection and capsule sequential therapy for patients with acute pulmonary bacterial infection is similar to that of levofloxacin hydrochloride injection alone, and the sequential treatment is more economical and safer than that of levofloxacin hydrochloride alone. It is worth popularizing and applying in clinic.
【作者单位】：遵义医学院附属医院药剂科;遵义医学院附属医院呼吸科;遵义医学院附属医院检验科;
【基金】：高等学校博士学科科研基金资助项目(200802260009)
【分类号】：R563.1

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