慢性阻塞性肺病稳定期患者生活质量与下呼吸道细菌定植及炎症反应的相关性
发布时间：2018-09-13 16:54
【摘要】：目的探讨慢性阻塞性肺病(COPD)稳定期患者生活质量与下呼吸道细菌定植及炎症反应的相关性。方法选择中重度COPD稳定期患者30例。对患者进行生活质量(SGRQ)问卷调查,记录各项得分。采集患者与志愿者痰液作为样本,统一进行细菌半定量培养。对受试者进行血清分离、血常规检查、血气分析、肺功能检测,各类检查结果进行统计学分析,探讨生活质量与下呼吸道细菌定植及炎症反应的相关性。结果经显微观察其中主要的定植细菌包括肺炎链球菌、洛菲不动杆菌和铜绿假单胞菌、(副)流感嗜血杆菌。血清化验结果显示,含有细菌定植的患者血清,IL-8的含量高于未含有细菌定植的患者和对照组(P0.01),FEV1%预计值和FEV1/FVC%要明显低于无细菌定植样品(P0.05);患者SGRQ问卷调查结果,总分、症状得分、活动得分、影响分的分布情况与IL-8呈正相关,同FEV1%预计值呈负相关(P0.01)。结论 COPD稳定期患者生活质量较健康人差,且部分患者存在细菌定植。细菌定植患者的生活质量较差,炎症反应较重,三者具有明显的相关性。
[Abstract]:Objective to investigate the relationship between quality of life (QOL) and bacterial colonization and inflammation in lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD). Methods 30 patients with moderate and severe COPD were selected. The quality of life (QOL) was investigated by (SGRQ) questionnaire, and the scores were recorded. The sputum of patients and volunteers were collected as samples and semi-quantitative culture of bacteria was carried out. Serum separation, blood routine examination, blood gas analysis, pulmonary function test, and statistical analysis were carried out to explore the correlation between quality of life and bacterial colonization and inflammation in lower respiratory tract. Results the main colonized bacteria were Streptococcus pneumoniae, Acinetobacter Lofiae, Pseudomonas aeruginosa and Haemophilus influenzae. The serum level of IL-8 in patients with bacterial colonization was significantly lower than that in patients without bacterial colonization (P0.01) and control group (P0.01). The distribution of activity score and influence score was positively correlated with IL-8 and negatively correlated with FEV1% prediction (P0.01). Conclusion the quality of life of COPD stable patients is worse than that of healthy people, and some patients have bacterial colonization. The quality of life of bacterial colonization patients was poor, and the inflammatory reaction was more serious.
【作者单位】： 广州市番禺区中心医院呼吸内科;
【基金】：2013年广州市科技攻关专项项目(No.201300000171)
【分类号】：R563.9
[Abstract]:Objective to investigate the relationship between quality of life (QOL) and bacterial colonization and inflammation in lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD). Methods 30 patients with moderate and severe COPD were selected. The quality of life (QOL) was investigated by (SGRQ) questionnaire, and the scores were recorded. The sputum of patients and volunteers were collected as samples and semi-quantitative culture of bacteria was carried out. Serum separation, blood routine examination, blood gas analysis, pulmonary function test, and statistical analysis were carried out to explore the correlation between quality of life and bacterial colonization and inflammation in lower respiratory tract. Results the main colonized bacteria were Streptococcus pneumoniae, Acinetobacter Lofiae, Pseudomonas aeruginosa and Haemophilus influenzae. The serum level of IL-8 in patients with bacterial colonization was significantly lower than that in patients without bacterial colonization (P0.01) and control group (P0.01). The distribution of activity score and influence score was positively correlated with IL-8 and negatively correlated with FEV1% prediction (P0.01). Conclusion the quality of life of COPD stable patients is worse than that of healthy people, and some patients have bacterial colonization. The quality of life of bacterial colonization patients was poor, and the inflammatory reaction was more serious.
【作者单位】： 广州市番禺区中心医院呼吸内科;
【基金】：2013年广州市科技攻关专项项目(No.201300000171)
【分类号】：R563.9
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