PCT联合凝血指标在ARDS患者预后判断中的价值
发布时间：2018-10-05 10:23
【摘要】：目的探讨炎性介质PCT联合凝血指标在ARDS患者预后判断中的价值,以及炎症指标与凝血指标之间的相关性。方法回顾性分析2014年1月至2016年1月期间入住重症监护病房(ICU)患者的临床资料。纳入确诊当天、第3天及第7天已行PCT水平及凝血指标(APTT、PT、FIB)水平检测的急性呼吸窘迫征(ARDS)患者50例。通过采用Spearman法与受试者工作特征(ROC)曲线,分析炎症指标PCT与凝血指标(APTT、PT、FIB)对患者生存情况的预测能力。结果死亡组PCT及凝血指标水平明显高于生存组(p0.05),在第3、7天死亡组患者PCT水平(64.786±13.343,80.372±17.534)明显高于存活组(5.110±2.789,2.295±0.942),尤其是第7天PCT水平,对预后的预测更有意义;凝血指标在两组治疗前后未发现太大差异,死亡组的APTT与PT较存活组任何时期都明显延长,而FIB明显减少;且PCT联合凝血指标预测患者预后的ROC(0.9520)明显高于单用PCT炎症因子或凝血指标预测患者预后的ROC(0.9437、0.951、0.9048、0.8859)。结论升高的PCT水平及异常的凝血指标预示患者预后越差、死亡风险越高,且PCT与凝血指标PT、FIB之间具有相关性。
[Abstract]:Objective to investigate the prognostic value of inflammatory mediators PCT combined with coagulation in patients with ARDS and the correlation between inflammatory markers and coagulation indexes. Methods the clinical data of (ICU) patients admitted to intensive care unit from January 2014 to January 2016 were analyzed retrospectively. Fifty patients with acute respiratory distress syndrome (ARDS) with acute respiratory distress were examined for PCT and APTT,PT,FIB on the third and seventh day of diagnosis. The predictive ability of inflammation index (PCT) and coagulation index (APTT,PT,FIB) on patients' survival was analyzed by using Spearman method and (ROC) curve. Results the levels of PCT and coagulation in the death group were significantly higher than those in the survival group (p0.05). The PCT level in the death group (64.786 卤13.343 卤80.372 卤17.534) was significantly higher than that in the survival group (5.110 卤2.789 卤2.295 卤0.942) on the 7th day, especially on the 7th day. There was no significant difference in coagulation parameters between the two groups before and after treatment. The APTT and PT in the death group were significantly longer than those in the survival group at any stage, but FIB was significantly decreased. The ROC (0.9520) of PCT combined with coagulation index was significantly higher than that of PCT inflammatory factor or coagulation index alone (0.94370.9041U 0.90480.8859). Conclusion the higher the level of PCT and the abnormal coagulation index, the worse the prognosis and the higher the risk of death. There is a correlation between PCT and PT,FIB.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.8
本文编号：2253025
[Abstract]:Objective to investigate the prognostic value of inflammatory mediators PCT combined with coagulation in patients with ARDS and the correlation between inflammatory markers and coagulation indexes. Methods the clinical data of (ICU) patients admitted to intensive care unit from January 2014 to January 2016 were analyzed retrospectively. Fifty patients with acute respiratory distress syndrome (ARDS) with acute respiratory distress were examined for PCT and APTT,PT,FIB on the third and seventh day of diagnosis. The predictive ability of inflammation index (PCT) and coagulation index (APTT,PT,FIB) on patients' survival was analyzed by using Spearman method and (ROC) curve. Results the levels of PCT and coagulation in the death group were significantly higher than those in the survival group (p0.05). The PCT level in the death group (64.786 卤13.343 卤80.372 卤17.534) was significantly higher than that in the survival group (5.110 卤2.789 卤2.295 卤0.942) on the 7th day, especially on the 7th day. There was no significant difference in coagulation parameters between the two groups before and after treatment. The APTT and PT in the death group were significantly longer than those in the survival group at any stage, but FIB was significantly decreased. The ROC (0.9520) of PCT combined with coagulation index was significantly higher than that of PCT inflammatory factor or coagulation index alone (0.94370.9041U 0.90480.8859). Conclusion the higher the level of PCT and the abnormal coagulation index, the worse the prognosis and the higher the risk of death. There is a correlation between PCT and PT,FIB.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.8
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