多索茶碱联合吸入用复方异丙托溴铵溶液治疗60例支气管哮喘急性发作的疗效和安全性

发布时间：2018-10-05 16:26

【摘要】：目的通过病例回顾性分析多索茶碱联合复方异丙托溴铵溶液(可必特)在支气管哮喘急性发作期治疗中临床疗效与安全性,为今后的用药方案提供思路。方法选取我院呼吸科于2015年1月~2016年1月收治的60例支气管哮喘急性发作患者的病例资料进行研究,随机将其平均分为对照组与观察组,每组各30例,对照组给予氨茶碱、地塞米松常规治疗;观察组在采用多索茶碱联合可必特治疗,并于治疗后对两组的疗效与不良反应进行对比分析。结果 (1)治疗后,观察组显效13例、有效15例、无效2例,总有效率为93.33%;对照组显效6例、有效17例、无效7例,总有效率为76.67%,观察组治疗总有效率明显高于对照组,差异具有统计学意义,P0.05。(2)治疗期间,观察组共发生嗜睡1例、心率减缓1例、腹泻1例,不良反应发生率为10%;对照组出现心率减缓2例、嗜睡1例、恶心呕吐1例、腹泻1例,不良反应发生率为13.33%,两组之间比较,差异不具有统计学意义,P0.05。结论在支气管哮喘急性发作期给予多索茶碱联合可必特治疗,可以有效缓解患者临床症状,提高肺功能,而且不良反应发生率低。
[Abstract]:Objective to retrospectively analyze the clinical efficacy and safety of doxophylline combined with compound ipratropium bromide solution in the treatment of bronchial asthma during acute attack. Methods the data of 60 patients with acute attack of bronchial asthma admitted to our hospital from January 2015 to January 2016 were studied and randomly divided into control group (n = 30) and observation group (n = 30). The control group was treated with aminophylline. The observation group was treated with doxophylline combined with codeine, and the curative effect and adverse reaction of the two groups were compared and analyzed after the treatment. Results (1) after treatment, there were 13 cases of remarkable effect, 15 cases of effective and 2 cases of ineffectiveness in the observation group, and the total effective rate was 93.3310 in the control group, 6 cases in the control group, 17 cases in the control group, 7 cases in ineffectiveness, the total effective rate was 76.677.The total effective rate in the observation group was significantly higher than that in the control group. The difference was statistically significant (P 0.05). (2) during the treatment period, there were 1 case of somnolence, 1 case of slow heart rate, 1 case of diarrhea and 1 case of adverse reaction in the observation group, while in the control group, there were 2 cases of heart rate slowing, 1 case of lethargy, 1 case of nausea and vomiting, and 1 case of diarrhea. The incidence of adverse reactions was 13.33. The difference between the two groups was not statistically significant (P 0.05). Conclusion Doxotheophylline combined with kebinol in acute stage of bronchial asthma can effectively relieve clinical symptoms and improve lung function, and the incidence of adverse reactions is low.
【作者单位】：洛阳北方企业集团有限公司职工医院内科;
【分类号】：R562.25

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