血清PCT、D-D及NT-proBNP对社区获得性肺部感染患者病情的评估研究

发布时间：2018-10-05 19:20

【摘要】：目的探讨血清PCT、D-D及NT-proBNP对社区获得性肺炎(CAP)患者病情的评估价值。方法选取2014年3月-2016年10月医院呼吸内科收治的社区获得性肺炎患者126例为CAP组;采用PSI评分评估患者病情,PSI得分130分为高危组(Ⅴ级),PSI得分91~130为中危组(Ⅳ级),PSI得分90分为低危组(Ⅰ~Ⅲ级);按住院期间存活情况,分为死亡组和存活组;选取同期于医院健康体检的人群120例为对照组;检测所有研究对象血清降钙素原(PCT)、D-二聚体(D-D)和N末端脑钠肽前体(NT-pro BNP)水平。结果 126例社区获得性肺炎患者中高危组33例占26.19%,中危组46例占36.51%,低危组47例占37.30%;CAP组血清PCT、D-D、NT-proBNP水平和PSI得分均显著高于对照组(P0.05),中危组和高危组高于低危组(P0.05),且高危组高于中危组(P0.05);血清PCT、D-D、NT-proBNP水平与PSI评分均呈正相关性(r=0.767,P=0.015;r=0.658,P=0.021;r=0.532,P=0.038);PCT高危社区获得性肺炎的诊断敏感性为92.6%,特异性91.2%;DD敏感性为85.6%,特异性93.5%;NT-proBNP敏感性为96.8%,特异性95.6%;死亡组血清PCT、D-D、NTproBNP水平均显著高于对照组(P0.05)。结论血清PCT、D-D、NT-proBNP水平与社区获得性肺炎的严重程度呈正相关性,可作为临床初始治疗和评估预后的参考指标。
[Abstract]:Objective to evaluate the value of serum PCT,D-D and NT-proBNP in the evaluation of (CAP) patients with community-acquired pneumonia. Methods A total of 126 patients with community-acquired pneumonia admitted to Department of Respiratory Medicine from March 2014 to October 2016 were selected as CAP group. According to the PSI score, the patients were divided into two groups: high risk group (grade 鈪，

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