喜炎平注射液治疗老年社区获得性肺炎（痰热壅肺证）临床疗效观察

发布时间：2018-10-13 18:30

【摘要】：目的:通过观察喜炎平注射液治疗老年社区获得性肺炎(痰热壅肺证)的临床症状、体征、48h退热情况、体温恢复正常所需时间、外周血白细胞、超敏C反应蛋白、降钙素原、白介素-6及肺CT炎症吸收的改善情况,评价喜炎平注射液治疗老年社区获得性肺炎(痰热壅肺证)临床疗效。方法:收入2016年6月至2017年2月解放军第463医院呼吸科病房收治的老年社区获得性肺炎(痰热壅肺证)患者80例,采用随机数字表法分为治疗组(喜炎平+西医常规治疗)和对照组(西医常规治疗)。疗程10天,10天后观察治疗组与对照组患者的主要症状(咳嗽、咳痰)、次要症状(发热、口渴、大便)、体征(湿Up音)、48h退热情况及体温恢复正常所需时间,外周血白细胞计数(White blood cell,WBC)、超敏C反应蛋白(High-sensitivity c-reactive protein,hs-CRP)、降钙素原(Procalcitonin,PCT)及血清白介素-6(interleukin-6,IL-6)改善情况及临床疗效。结果:1.在临床疗效方面,治疗组总有效率为92.5%,对照组总有效率为82.05%。治疗组优于对照组(P0.05)。2.在中医证候评分及退热时间方面,治疗组治疗后中医证候评分、总积分(除口渴、大便外)、48h退热情况及体温恢复正常所需时间均较对照组改善明显(P0.05)。3.在抗感染方面,两组外周血WBC、hs-CRP、IL-6及肺部CT炎症吸收情况,治疗后组间比较治疗组优于对照组,有统计学差异(P0.05),PCT治疗后组间比较无统计学差异(P0.05)。结论:1.西医常规治疗基础上加用喜炎平注射液治疗老年社区获得性肺炎(痰热壅肺证)的临床疗效显著。2.西医常规治疗基础上加用喜炎平注射液治疗老年社区获得性肺炎(痰热壅肺证),在临床症状(咳嗽、咳痰、发热)、体征(湿Up音)、总积分及48h退热情况及体温恢复正常所需时间方面,均优于西医常规治疗,利于疾病转归且能够缩短患者退热时间及发热天数。3.西医常规治疗基础上加用喜炎平注射液治疗老年社区获得性肺炎(痰热壅肺证),能进一步改善外周血WBC、hs-CRP、IL-6,肺部CT炎症吸收情况从而促进炎症吸收。
[Abstract]:Objective: to observe the clinical symptoms, signs, 48 h antipyretic condition, the time required for body temperature recovery, peripheral white blood cells, hypersensitive C-reactive protein, procalcitonin in the treatment of senile community-acquired pneumonia with Xiyanping injection. To evaluate the clinical effect of Xiyanping injection in the treatment of senile community-acquired pneumonia (syndrome of phlegm-heat obstruction of lung). Methods: from June 2016 to February 2017, 80 elderly patients with community acquired pneumonia (syndrome of phlegm and heat obstructing the lung) were admitted to the respiratory ward of the 463 Hospital of PLA. The patients were randomly divided into two groups: treatment group (routine treatment of Xiyanping western medicine) and control group (routine treatment of western medicine). After 10 days of treatment, the main symptoms (cough, expectoration), secondary symptoms (fever, thirst, stool), physical signs (wet Up sound), 48 h antipyretic condition and the time needed for body temperature to return to normal were observed in the treatment group and the control group. Peripheral blood leukocyte count (White blood cell,WBC), hypersensitive C-reactive protein (High-sensitivity c-reactive protein,hs-CRP), procalcitonin (Procalcitonin,PCT) and serum interleukin-6 (interleukin-6,IL-6) were improved and their clinical efficacy was evaluated. The result is 1: 1. The total effective rate was 92.5 in the treatment group and 82.05 in the control group. The treatment group was superior to the control group (P0.05). In TCM syndrome score and antipyretic time, the treatment group after treatment TCM syndrome score, total score (except thirst, stool), 48h antipyretic condition and temperature recovery time were significantly improved compared with the control group (P0.05). In the aspect of anti-infection, the inflammatory absorption of WBC,hs-CRP,IL-6 in peripheral blood and lung CT in the two groups was better than that in the control group after treatment. There was no statistical difference between the two groups (P0.05) after), PCT treatment (P0.05). Conclusion: 1. On the basis of routine treatment of western medicine plus Xiyanping injection in the treatment of elderly community acquired pneumonia (phlegm heat obstruction lung syndrome) the clinical efficacy is significant. 2. On the basis of routine treatment of western medicine, combined with Xiyanping injection to treat elderly community-acquired pneumonia (phlegm-heat obstruction of lung syndrome), in clinical symptoms (cough, expectoration, phlegm), Fever), physical sign (wet Up sound), total score, 48 h antipyretic condition and the time needed for body temperature to return to normal were better than that of western medicine routine treatment, which was beneficial to the outcome of the disease and could shorten the time of fever and the days of fever. On the basis of routine treatment of western medicine, the treatment of elderly community-acquired pneumonia (phlegm-heat obstruction of lung syndrome) with Xiyanping injection can further improve the inflammatory absorption of peripheral blood WBC,hs-CRP,IL-6, lung CT and thus promote inflammatory absorption.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.1

【参考文献】