抗菌药物联合痰热清注射液治疗肺癌患者化疗后继发肺部感染的临床疗效研究

发布时间：2018-10-16 17:44

【摘要】：目的探究抗菌药物联合痰热清注射液治疗肺癌患者化疗后继发肺部感染的临床疗效观察。方法选取2014年1月-2016年12月医院收治的120例肺癌患者化疗后继发肺部感染的患者作为研究对象,将患者分为试验组和对照组,每组60例;对照组采用抗菌药物联合治疗,试验组在对照组的基础上加用痰热清注射液治疗,治疗两个疗程,比较两组患者临床指标及有效率。结果治疗后,试验组治疗总有效率为96.67%,高于对照组的86.67%(P0.05);试验组的机体功能状态改善情况的总有效率为98.33%,高于对照组的85.00%(P0.05);试验组临床症状消失的时间少于对照组(P0.05);试验组血清MMP-9、TNF-α和IL-8的水平下降,且低于对照组(P0.05);试验组的住院时间少于对照组(P0.05);试验组未发生二重感染,对照组的二重感染的感染率为4.14%(P0.05)。结论痰热清注射液与抗菌药物联合治疗肺癌患者化疗后的继发肺部感染,疗效显著,发挥了较好的止咳、抗炎、化痰的功效。
[Abstract]:Objective to investigate the clinical efficacy of antimicrobial agents combined with Tanreqing injection in the treatment of pulmonary infection secondary to chemotherapy in patients with lung cancer. Methods from January 2014 to December 2016, 120 cases of lung cancer patients with secondary pulmonary infection after chemotherapy were selected as study objects. The patients were divided into experimental group and control group with 60 cases in each group, and the control group was treated with antimicrobial agents. The experimental group was treated with Tanreqing injection on the basis of the control group and two courses of treatment were used to compare the clinical indexes and the effective rate of the two groups. Results after treatment, The total effective rate of treatment in the test group was 96.67%, which was higher than that in the control group (86.67%, P0.05); the total effective rate of the improvement of the body function in the test group was 98.33, higher than that in the control group (85.00%, P0.05); the time of clinical symptom disappearance in the test group was less than that in the control group (P0.05); the serum MMP-9,TNF- 伪 in the test group was lower than that in the control group (P0.05). And the level of IL-8, And lower than the control group (P0.05); the test group was less than the control group (P0.05); the experimental group did not have double infection, the infection rate of the control group was 4.14% (P0.05). Conclusion the combination of Tanreqing injection and antimicrobial agents in the treatment of lung cancer patients with secondary lung infection after chemotherapy has a significant effect on cough, anti-inflammatory, phlegm.
【作者单位】： 南充市中心医院药学部;南充市中心医院肿瘤中心;南充市中心医院呼吸内科;
【基金】：四川省科技厅研究基金资助项目(2012SZ0188)
【分类号】：R563.1;R734.2

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