左西孟旦与米力农治疗顽固性心力衰竭合并呼吸衰竭患者疗效比较

发布时间：2018-10-17 09:14

【摘要】：目的探讨左西孟旦、米力农治疗顽固性心力衰竭合并呼吸衰竭患者的临床效果。方法选取呼吸衰竭合并性顽固性心力衰竭患者60例,随机分为A、B组各30例。两组均给予机械通气、抗感染、化痰祛痰、扩冠、利尿、减少心肌耗氧量、改善心肌重构等治疗。在此基础上,A组加用左西孟旦治疗,B组加用米力农治疗。记录两组治疗7 d脱离呼吸机(脱机)、拔除气管插管(拔管)例数及治疗过程中呼吸机支持压力(PS)、氧浓度变化,检测血清氨基末端脑钠钛前体(NT-pro BNP)水平、左心室射血分数(LVEF)。结果治疗前后比较,两组呼吸机PS、氧浓度、血清NTpro BNP水平下降,LVEF升高(P均0.05)。与B组比较,治疗7 d A组脱机率及拔管率升高,治疗第3、7天呼吸机PS、氧浓度下降,血清NT-pro BNP水平下降,LVEF升高,两组比较差异均有统计学意义(P均0.05)。结论左西孟旦、米力农对呼吸衰竭合并顽固性心力衰竭患者的呼吸功能及心脏功能均有改善作用,左西孟旦优势更明显。
[Abstract]:Objective to investigate the clinical effect of levosimendan and milrinone in the treatment of refractory heart failure complicated with respiratory failure. Methods 60 patients with respiratory failure complicated with refractory heart failure were randomly divided into group A (n = 30) and group B (n = 30). Both groups were treated with mechanical ventilation, anti-infection, phlegm expelling, crown expanding, diuretic, reducing myocardial oxygen consumption and improving myocardial remodeling. On this basis, group A was treated with levosimendan and group B with milrinone. The number of patients with tracheal intubation (extubation) and the changes of oxygen concentration of ventilator support pressure (PS),) during the treatment were recorded. Serum amino-terminal brain natrium precursor (NT-pro BNP) and left ventricular ejection fraction (LVEF).) were measured. Results compared with before and after treatment, the oxygen concentration of ventilator PS, the level of serum NTpro BNP decreased, and the level of LVEF increased in both groups (P < 0. 05). Compared with group B, the weaning rate and extubation rate in group A were higher than those in group B, the oxygen concentration of ventilator PS, and the level of serum NT-pro BNP and LVEF in group A were lower than those in group B on the 3rd day of treatment. The difference between the two groups was statistically significant (P 0.05). Conclusion levosimendan and milrinone can improve respiratory function and cardiac function in patients with respiratory failure and refractory heart failure.
【作者单位】：青岛市胶州中心医院;
【分类号】：R541.6;R563.8

【相似文献】