慢性阻塞性肺疾病患者膈肌厚度分数与活动耐力和呼吸困难相关性研究
发布时间：2018-10-17 14:17
【摘要】：目的观察慢性阻塞性肺疾病(慢阻肺)患者膈肌厚度变化,评价其与活动耐力和呼吸困难的关系。方法选取2015年8月至2016年8月上海市东方医院呼吸门诊收治的慢阻肺患者50例,同时选取该院职工肺功能正常的30名年龄与之接近的健康人作为对照组。分别行肺功能检查,在功能残气(FRC)、肺总量(TLC)位超声测量膈肌厚度(TD),计算膈肌厚度分数(TF,从FRC至TLC位膈肌厚度的变化),6 min步行距离(6MWT)、呼吸困难指数(m MRC);分析慢阻肺患者TD变化与肺功能和活动能力的相关性。结果慢阻肺组TLC位膈肌厚度和厚度分数分别为(0.38±0.10)cm和1.02±0.45,与健康对照组[(0.49±0.09)cm和(1.41±0.47)]比较差异有统计学意义(P0.05)。厚度分数与6MWT呈正相关(r=0.591,P0.01),与m MRC呈负相关(r=-0.472,P=0.001)。根据厚度分数水平,将慢阻肺组分为2亚组:G1(≤1.458),G2(1.458)。G1组6MWT为(371.95±95.73)m,较G2组[(512.00±108.61)m]降低(P0.05);G1组mMRC为2.63±1.08,较G2组(1.70±0.82)增高(P0.05);G1组气道阻塞(FEV_1)为(47.41±16.70)L,最大自主通气量(MVV)为(46.32±17.97)L,两者较G2组[FEV_1为(69.96±16.82)L,MVV(62.60±22.13)L]下降(均P0.05)。结论慢阻肺患者膈肌厚度和厚度分数下降影响患者活动耐力和呼吸困难。
[Abstract]:Objective to observe the changes of diaphragm thickness in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the relationship between diaphragm thickness and activity tolerance and dyspnea. Methods from August 2015 to August 2016, 50 patients with chronic obstructive pulmonary disease (COPD) were selected from respiratory outpatient department of Shanghai Oriental Hospital, and 30 healthy people whose lung function were normal were selected as control group. Lung function tests were performed separately, Measurement of diaphragmatic thickness by ultrasound at total lung volume of (FRC), and (TD), (change of diaphragm thickness from FRC to TLC in TF,), 6 min walking distance (6MWT), (m MRC); analysis of TD and pulmonary function in COPD patients with dyspnea index (m MRC);) And the relevance of the activity ability. Results the diaphragm thickness and thickness fraction in TLC group were (0.38 卤0.10) cm and (1.02 卤0.45) cm, respectively, which were significantly different from those in healthy control group [(0.49 卤0.09) cm and (1.41 卤0.47)] (P0.05). The thickness fraction was positively correlated with 6MWT (r = 0.591, P 0.01) and negatively correlated with m MRC (r = 0.472P ~ (0.001). 鏍规嵁鍘氬害鍒嗘暟姘村钩,灏嗘參闃昏偤缁勫垎涓，
本文编号：2276945
[Abstract]:Objective to observe the changes of diaphragm thickness in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the relationship between diaphragm thickness and activity tolerance and dyspnea. Methods from August 2015 to August 2016, 50 patients with chronic obstructive pulmonary disease (COPD) were selected from respiratory outpatient department of Shanghai Oriental Hospital, and 30 healthy people whose lung function were normal were selected as control group. Lung function tests were performed separately, Measurement of diaphragmatic thickness by ultrasound at total lung volume of (FRC), and (TD), (change of diaphragm thickness from FRC to TLC in TF,), 6 min walking distance (6MWT), (m MRC); analysis of TD and pulmonary function in COPD patients with dyspnea index (m MRC);) And the relevance of the activity ability. Results the diaphragm thickness and thickness fraction in TLC group were (0.38 卤0.10) cm and (1.02 卤0.45) cm, respectively, which were significantly different from those in healthy control group [(0.49 卤0.09) cm and (1.41 卤0.47)] (P0.05). The thickness fraction was positively correlated with 6MWT (r = 0.591, P 0.01) and negatively correlated with m MRC (r = 0.472P ~ (0.001). 鏍规嵁鍘氬害鍒嗘暟姘村钩,灏嗘參闃昏偤缁勫垎涓，
本文编号：2276945
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