瑞舒伐他汀对大鼠实验性肺血栓栓塞症血浆NT-pro-BNP和IL-6水平的干预作用
发布时间：2018-10-19 18:29
【摘要】：[目的]1.研究炎症反应是否参与肺栓塞的发展。 2.讨论瑞舒伐他汀对肺血栓栓塞症是否有治疗作用。 [方法]选取健康、雄性的Wistar大鼠45只,大鼠周龄为6-8,体重在180-220g之间,随机分呈3组,每组15只大鼠,A组为对照组、B组为肺栓塞模型组,C组为实验组(经瑞舒伐他汀干预的肺栓塞大鼠),实验前经尾静脉取血制备字体血栓,A、B组以生理盐水灌胃3天,C组以5mg/kg*d瑞舒伐他汀灌胃3天,B、C组经颈静脉注射含栓子的生理盐水2ml。24h后采三组大鼠血,每只大鼠取4毫升,通过双抗体夹心法方法测定BNP及IL-6的浓度。 [结果]A组与B组、C组及B组之间NT-pro-BNP、IL-6值均有统计学差异(P0.05),A组的血浆NT-pro-BNP为(12.57±2.20)pg/L,B组血浆NT-pro-BNP为(42.14±4.52)pg/L,C组的血浆NT-pro-BNP为(21.03±1.98)pg/L；A组的血浆IL-6为(61.36±14.25)pg/L,B组血浆NT-pro-BNP为(92.54±12.85)pg/L,C组的血浆NT-pro-BNP为(70.31±14.20)pg/L,A组与B组、C组与B组之间比较差异有统计学意义(P0.05)。 [结论]1炎症反应参与了肺栓塞的发展。 2瑞舒伐他汀对肺栓塞有治疗作用。
[Abstract]:[objective] 1. To study whether inflammatory response is involved in the development of pulmonary embolism. 2. To discuss the therapeutic effect of rosuvastatin on pulmonary thromboembolism. [methods] Forty-five healthy, male Wistar rats were randomly divided into 3 groups, aged 6-8 and weighing between 180-220 g. There were 15 rats in each group, A group as control group, B group as pulmonary embolism model group, C group as experimental group (pulmonary embolism rats treated by recuvastatin). The rats in group B were given 5mg/kg*d recuvastatin for 3 days, and rats in group C were injected with saline 2ml.24h containing embolus via jugular vein for 3 days. The concentrations of BNP and IL-6 were determined by double antibody sandwich method. [results] there was significant difference in NT-pro-BNP,IL-6 between group A and group B, group C and group B (P0.05 in), A group, plasma NT-pro-BNP was (12.57 卤2.20) pg/L,B), plasma NT-pro-BNP was (42.14 卤4.52) pg/L,C, plasma NT-pro-BNP was (21.03 卤1.98) pg/L;. The plasma IL-6 of group A was (61.36 卤14.25) pg/L,B, the plasma NT-pro-BNP of group A was (92.54 卤12.85) pg/L,C, the plasma NT-pro-BNP of group A was (70.31 卤14.20) pg/L,A and group B, the difference between group C and group B was statistically significant (P0.05). [conclusion] 1 inflammatory reaction is involved in the development of pulmonary embolism. 2 Risuvastatin has therapeutic effect on pulmonary embolism.
【学位授予单位】：滨州医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.5
本文编号：2281992
[Abstract]:[objective] 1. To study whether inflammatory response is involved in the development of pulmonary embolism. 2. To discuss the therapeutic effect of rosuvastatin on pulmonary thromboembolism. [methods] Forty-five healthy, male Wistar rats were randomly divided into 3 groups, aged 6-8 and weighing between 180-220 g. There were 15 rats in each group, A group as control group, B group as pulmonary embolism model group, C group as experimental group (pulmonary embolism rats treated by recuvastatin). The rats in group B were given 5mg/kg*d recuvastatin for 3 days, and rats in group C were injected with saline 2ml.24h containing embolus via jugular vein for 3 days. The concentrations of BNP and IL-6 were determined by double antibody sandwich method. [results] there was significant difference in NT-pro-BNP,IL-6 between group A and group B, group C and group B (P0.05 in), A group, plasma NT-pro-BNP was (12.57 卤2.20) pg/L,B), plasma NT-pro-BNP was (42.14 卤4.52) pg/L,C, plasma NT-pro-BNP was (21.03 卤1.98) pg/L;. The plasma IL-6 of group A was (61.36 卤14.25) pg/L,B, the plasma NT-pro-BNP of group A was (92.54 卤12.85) pg/L,C, the plasma NT-pro-BNP of group A was (70.31 卤14.20) pg/L,A and group B, the difference between group C and group B was statistically significant (P0.05). [conclusion] 1 inflammatory reaction is involved in the development of pulmonary embolism. 2 Risuvastatin has therapeutic effect on pulmonary embolism.
【学位授予单位】：滨州医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.5
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