补肺活血化痰汤联合正压通气治疗COPD急性加重并发严重呼吸衰竭效果观察

发布时间：2018-10-22 18:37

【摘要】：目的观察补肺活血化痰汤联合正压通气治疗慢性阻塞性肺疾病(COPD)急性加重并发严重呼吸衰竭的效果。方法 COPD急性加重并发严重呼吸衰竭患者60例,其中给予正压通气治疗30例(单通气组)、补肺活血化痰汤联合正压通气治疗30例(联合组)。治疗后12周进行中医症候疗效判断,通气前、治疗后24 h进行动脉血气分析并检测患者血浆脑钠肽水平。结果治疗后12周联合组中医症候总有效率高于单通气组(P均0.05)。治疗后24 h,两组动脉血pH、Pa O2均较通气前高,Pa CO2低(P均0.05)。治疗后24 h,联合组、单通气组血浆脑钠肽水平均较通气前低(P均0.05),且联合组较单通气组低(P0.05)。结论补肺活血化痰汤联合正压通气治疗能有效提高COPD急性加重并发严重呼吸衰竭患者的中医症候疗效,改善动脉血气,降低血浆脑钠肽水平。
[Abstract]:Objective to observe the effect of Bufei Huoxue Huatan decoction combined with positive pressure ventilation on acute exacerbation of chronic obstructive pulmonary disease (COPD) with severe respiratory failure. Methods 60 patients with acute exacerbation of COPD complicated with severe respiratory failure were treated with positive pressure ventilation (30 cases) and 30 cases (combined group) with Bufei Huoxue Huatan decoction combined with positive pressure ventilation. After 12 weeks of treatment, the therapeutic effect of TCM symptoms was judged. Before ventilation and 24 hours after treatment, arterial blood gas was analyzed and plasma brain natriuretic peptide levels were measured. Results 12 weeks after treatment, the total effective rate of TCM symptoms in the combined group was higher than that in the single ventilation group (P 0.05). 24 hours after treatment, the arterial blood pH,Pa O 2 was higher and Pa CO2 was lower in both groups than before ventilation (P 0.05). 24 hours after treatment, the plasma BNP levels in the combined group and single ventilation group were lower than those before ventilation (P 0.05), and those in the combined group were lower than those in the single ventilation group (P0.05). Conclusion Bufei Huoxue Huatan decoction combined with positive pressure ventilation can effectively improve the curative effect of TCM symptoms in patients with acute exacerbation of COPD complicated with severe respiratory failure, improve arterial blood gas, and reduce the level of plasma brain natriuretic peptide.
【作者单位】：江南大学附属医院无锡市第四人民医院;
【分类号】：R563

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