慢性阻塞性肺疾病患者与肺功能正常吸烟者CT肺实质灌注成像对照

发布时间：2018-10-31 14:45

【摘要】：目的分析慢性阻塞性肺疾病(COPD)患者及肺功能正常吸烟者CT肺实质灌注图像的差异。方法对63例COPD患者及20名肺功能正常吸烟者(对照组)行肺CTPI,将COPD患者分为轻度亚组(16例)、中度亚组(18例)、重度亚组(11例)和极重度亚组(18例),在肺叶水平计算灌注缺损区与正常区CT值比值(RHU),比较各组体质量指数(BMI)、吸烟量及各肺叶RHU的差异。结果对照组BMI与重度、极重度COPD亚组比较,对照组吸烟量与极重度COPD亚组比较差异均有统计学意义(P=0.006、0.002、0.007)。同组各肺叶RHU差异均无统计学意义(P均0.05)。对照组右肺下叶RHU与重度、极重度COPD亚组差异有统计学意义(P=0.03、0.02),其他各肺叶RHU各组差异均无统计学意义(P均0.05)。对照组与各COPD亚组RHU差异均有统计学意义(P均0.05);轻度与重度、与极重度COPD亚组,中度与极重度COPD亚组RHU差异均有统计学意义(P=0.022、0.001、0.003)。结论 RHU可区分COPD和肺功能正常吸烟者,有可能成为评估COPD严重程度的指标之一。
[Abstract]:Objective to analyze the difference of pulmonary parenchyma perfusion images of CT in patients with chronic obstructive pulmonary disease (COPD) and normal smokers. Methods 63 patients with COPD and 20 normal smokers (control group) were divided into mild subgroup (16 cases), moderate subgroup (18 cases), severe subgroup (11 cases) and extremely severe subgroup (18 cases), which were divided into three groups: mild subgroup (16 cases), moderate subgroup (18 cases), severe subgroup (11 cases) and extremely severe subgroup (18 cases). The ratio of CT value of perfusion defect area to normal area was calculated at the pulmonary lobe level to compare the smoking volume of (BMI), and the RHU of each lung lobe in each group. Results there were significant differences in BMI between the control group and the severe and very severe COPD subgroup, and between the control group and the very severe COPD subgroup (P0. 006, 0. 002, 0. 007). There was no significant difference in RHU in all lobes of the same group (all P 0. 05). In the control group, RHU in the right lower lobe was significantly different from that in the severe and very severe COPD subgroups (P0. 03, 0. 02), but no significant difference was found in other lobar RHU groups (all P 0. 05). The difference of RHU between control group and COPD subgroup was statistically significant (P 0.05), and that between mild and severe COPD subgroup, moderate COPD subgroup and very severe COPD subgroup was statistically significant (P0. 022 + 0. 001t0. 003). Conclusion RHU can distinguish COPD from normal smokers and may be one of the indexes to evaluate the severity of COPD.
【作者单位】：第二军医大学附属长征医院影像科;
【基金】：国家自然科学基金青年基金项目(81000602) 上海市自然科学基金(10ZR1438900)
【分类号】：R563.9

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