胸腺五肽对老年慢性阻塞性肺病患者肺功能、细胞免疫功能及炎症因子的影响

发布时间：2018-11-02 11:54

【摘要】：目的探讨胸腺五肽对老年慢性阻塞性肺病(COPD)患者的肺功能、细胞免疫功能及炎症因子的影响。方法 60名老年COPD稳定期患者纳入研究,随机分为治疗组和对照组各30例。对照组患者给予常规药物治疗和间歇低流量吸氧治疗,治疗组30例在常规治疗的基础上加用胸腺五肽10 mg,皮下注射,1周2次,连续3个月。两组患者分别于治疗前和治疗3个月后检测肺功能,测定细胞因子水平的变化及T细胞亚群的改变。结果治疗组患者经过治疗后T细胞亚群(CD3+、CD4+和CD4+/CD8+)较治疗前和常规对照组明显升高(P0.05),CD8+、hs-CRP、IL-6和TNF-α较治疗前和对照组均明显下降(P0.05);两组患者FEV1、FEV1/FVC和PEF均较治疗前明显上升(均P0.05)。结论胸腺五肽可显著提高老年COPD患者的细胞免疫功能,减少炎症反应,改善肺功能。
[Abstract]:Objective to investigate the effects of thymus pentapeptide on pulmonary function, cellular immune function and inflammatory factors in elderly patients with chronic obstructive pulmonary disease (COPD). Methods 60 elderly patients with stable COPD were randomly divided into treatment group (n = 30) and control group (n = 30). Patients in the control group were treated with routine drug therapy and intermittent low-flow oxygen inhalation. 30 patients in the treatment group were subcutaneously injected with thymic pentapeptide for 10 mg, on the basis of routine treatment, twice a week for 3 months. Lung function, cytokine levels and T cell subsets were measured before and 3 months after treatment in both groups. Results after treatment, T cell subsets (CD3, CD4 and CD4 / CD8) in treatment group were significantly higher than those before treatment and routine control group (P0.05), CD8, hs-CRP,. IL-6 and TNF- 伪 were significantly lower than those before treatment and control group (P0.05). FEV1,FEV1/FVC and PEF in both groups were significantly higher than those before treatment (P0.05). Conclusion Thymosin can significantly improve cellular immune function, reduce inflammatory reaction and improve lung function in elderly patients with COPD.
【作者单位】：武汉市中心医院综合一科;
【分类号】：R563.9

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