可溶性髓样细胞触发型受体sTREM-1在肺部感染的诊断意义
发布时间：2018-11-04 09:45
【摘要】：目的： 通过检测肺部感染患者外周血中可溶性髓样细胞触发型受体-1（sTREM-1）、降钙素原（PCT）、C-反应蛋白（CRP）的水平，观察sTREM-1在肺部感染中的诊断意义以及在CAP和HAP中是否存在差异，并探讨其临床应用价值。 方法： 采用ELISA法检测试验组（30例社区获得性肺炎患者、18例医院获得性肺炎患者）及对照组（14例弥漫性肺疾病患者）外周血中sTREM-1、PCT、CRP水平，并计算出各项指标的敏感性、特异性及诊断符合率。 结果： （1）CAP组血清中的sTREM-1（99.71±111.17）pg/ml、PCT（10.26±22.02）ug/ml均明显高于对照组（P＜0.05）；（2） HAP组血清中的sTREM-1（117.40±134.73）pg/ml、PCT（8.67±9.11）ug/ml均明显高于对照组（P＜0.05）；（3）CAP组和HAP组血清中的sTREM-1、PCT、CRP无明显差异（P＞0.05）；（4）根据ROC曲线得出sTREM-1的最佳阈值为38.13pg/ml，以此为标准CAP诊断的敏感性为0.900，特异性为0.786，诊断符合率为0.864，高于同组CRP（P＜0.05）；其诊断的敏感性和诊断符合率高于同组PCT（P＜0.05）；HAP诊断的敏感性为0.889，，特异性为0.786，诊断符合率为0.844，高于同组CRP（P＜0.05）；其诊断的敏感性和诊断符合率高于同组PCT（P＜0.05）；sTREM-1的特异性为0.786，与PCT无明显差异；（5）CAP组及HAP组中sTREM-1+PCT联合检测的敏感性、特异性和诊断符合率高于sTREM-1单独检测（P＜0.05）。 结论： 1、CAP、 HAP血清中的sTREM-1、PCT、CRP的水平明显升高，sTREM-1和PCT的敏感性、特异性和诊断符合率优于CRP；sTREM-1的敏感性和诊断符合率高于PCT； 2、sTREM-1联合检测PCT能提高CAP和HAP诊断的敏感性、特异性和诊断符合率； 3.CAP、 HAP血清中的sTREM-1、PCT和CRP的水平无明显差异。
[Abstract]:Objective: to detect the levels of soluble myeloid cell trigger receptor-1 (sTREM-1) and procalcitonin (PCT), C-reactive protein (CRP) in peripheral blood of patients with pulmonary infection. To observe the diagnostic significance of sTREM-1 in pulmonary infection and whether there are differences between CAP and HAP, and to explore its clinical application value. Methods: the levels of sTREM-1,PCT,CRP in peripheral blood of the test group (30 patients with community-acquired pneumonia, 18 patients with hospital acquired pneumonia) and the control group (14 patients with diffuse pulmonary disease) were detected by ELISA method. The sensitivity, specificity and diagnostic coincidence rate were calculated. Results: (1) the serum sTREM-1 of CAP group (99.71 卤111.17) pg/ml,PCT (10.26 卤22.02) ug/ml was significantly higher than that of control group (P < 0. 05). (2) the serum sTREM-1 of HAP group (117.40 卤134.73) pg/ml,PCT (8.67 卤9.11) ug/ml was significantly higher than that of control group (P < 0. 05). (3) there was no significant difference in serum sTREM-1,PCT,CRP between CAP group and HAP group (P > 0. 05). (4) according to the ROC curve, the optimal threshold of sTREM-1 was 38.13 PG / ml. The diagnostic sensitivity and specificity of CAP were 0.900 and 0.786, respectively. The diagnostic coincidence rate was 0.864, which was higher than that of the same group (CRP (P < 0.05). The diagnostic sensitivity and diagnostic coincidence rate were higher than that of PCT (P < 0. 05); HAP in the same group (0. 889, specificity 0. 786, the diagnostic coincidence rate was 0. 844, higher than that in the same group CRP (P < 0. 05). Its diagnostic sensitivity and diagnostic coincidence rate were higher than those of the same group (PCT (P < 0. 05), the specificity of sTREM-1 was 0. 786, there was no significant difference between sTREM-1 and PCT. (5) the sensitivity, specificity and diagnostic coincidence rate of sTREM-1 PCT in CAP group and HAP group were higher than those in sTREM-1 alone (P < 0. 05). Conclusion: 1 the level of sTREM-1,PCT,CRP in serum of CAP and HAP is significantly increased, the sensitivity, specificity and diagnostic coincidence rate of sTREM-1 and PCT are higher than that of CRP;sTREM-1 and the diagnostic coincidence rate is higher than that of PCT;. (2) combined detection of PCT with sTREM-1 could improve the sensitivity, specificity and diagnostic coincidence rate of CAP and HAP, but there was no significant difference in the levels of sTREM-1,PCT and CRP between HAP and HAP.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563
本文编号：2309462
[Abstract]:Objective: to detect the levels of soluble myeloid cell trigger receptor-1 (sTREM-1) and procalcitonin (PCT), C-reactive protein (CRP) in peripheral blood of patients with pulmonary infection. To observe the diagnostic significance of sTREM-1 in pulmonary infection and whether there are differences between CAP and HAP, and to explore its clinical application value. Methods: the levels of sTREM-1,PCT,CRP in peripheral blood of the test group (30 patients with community-acquired pneumonia, 18 patients with hospital acquired pneumonia) and the control group (14 patients with diffuse pulmonary disease) were detected by ELISA method. The sensitivity, specificity and diagnostic coincidence rate were calculated. Results: (1) the serum sTREM-1 of CAP group (99.71 卤111.17) pg/ml,PCT (10.26 卤22.02) ug/ml was significantly higher than that of control group (P < 0. 05). (2) the serum sTREM-1 of HAP group (117.40 卤134.73) pg/ml,PCT (8.67 卤9.11) ug/ml was significantly higher than that of control group (P < 0. 05). (3) there was no significant difference in serum sTREM-1,PCT,CRP between CAP group and HAP group (P > 0. 05). (4) according to the ROC curve, the optimal threshold of sTREM-1 was 38.13 PG / ml. The diagnostic sensitivity and specificity of CAP were 0.900 and 0.786, respectively. The diagnostic coincidence rate was 0.864, which was higher than that of the same group (CRP (P < 0.05). The diagnostic sensitivity and diagnostic coincidence rate were higher than that of PCT (P < 0. 05); HAP in the same group (0. 889, specificity 0. 786, the diagnostic coincidence rate was 0. 844, higher than that in the same group CRP (P < 0. 05). Its diagnostic sensitivity and diagnostic coincidence rate were higher than those of the same group (PCT (P < 0. 05), the specificity of sTREM-1 was 0. 786, there was no significant difference between sTREM-1 and PCT. (5) the sensitivity, specificity and diagnostic coincidence rate of sTREM-1 PCT in CAP group and HAP group were higher than those in sTREM-1 alone (P < 0. 05). Conclusion: 1 the level of sTREM-1,PCT,CRP in serum of CAP and HAP is significantly increased, the sensitivity, specificity and diagnostic coincidence rate of sTREM-1 and PCT are higher than that of CRP;sTREM-1 and the diagnostic coincidence rate is higher than that of PCT;. (2) combined detection of PCT with sTREM-1 could improve the sensitivity, specificity and diagnostic coincidence rate of CAP and HAP, but there was no significant difference in the levels of sTREM-1,PCT and CRP between HAP and HAP.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563
【参考文献】
相关期刊论文 前4条
1 徐志康;陈望;刘和录;刘镇平;华建江;赖剑波;朱兆钧;汪奇云;;利用ROC曲线分析sTREM-1、PCT和CRP对多发伤早期感染的诊断价值[J];中国实验诊断学;2011年11期
2 戴然然;刘嘉琳;周敏;程齐俭;李庆云;万欢英;;血清可溶性髓系细胞触发受体-1检测在细菌性肺炎诊断中的意义[J];诊断学理论与实践;2010年05期
3 田作军;赵薛旭;李作汉;张帆;曹福田;李少明;邵明;董亚贤;;应用ROC曲线评价髓鞘碱性蛋白对多发性硬化的诊断价值[J];南方医科大学学报;2009年02期
4 林乐平,滕斌;C-反应蛋白在老年社区获得性下呼吸道感染中的临床价值[J];临床肺科杂志;2004年04期
本文编号：2309462
本文链接：https://www.wllwen.com/yixuelunwen/huxijib/2309462.html
最近更新
教材专著
