石家庄地区应用防霾措施预防COPD患者急性加重的临床疗效

发布时间：2018-11-05 06:46

【摘要】：目的观察在石家庄地区应用防雾霾措施预防慢性阻塞性肺疾病(CODP)患者病情急性加重的治疗效果。方法选取2013年1月~2015年8月本院治疗并定期随访的140例COPD患者作为研究对象,随机分为观察组和对照组,各70例。对照组患者采用常规治疗,观察组在对照组患者的基础上加用佩戴PM2.5防护口罩、应用空气净化器等雾霾防护措施。观察比较两组患者COPD急性加重发生情况、肺功能变化情况和治疗费用情况以评价两组患者的治疗效果。结果观察组共64例患者完成研究,对照组共68例患者完成研究;观察组患者AECOPD平均发作次数明显少于对照组,差异有统计学意义(F=30.75,P0.01);治疗前两组患者FEV_1/FVC差异无统计学意义(P0.05),治疗后观察组患者FEV_1/FVC明显提高(P0.01),对照组患者FEV_1/FVC轻度降低(P=0.86),观察组患者FEV_1/FVC明显优于对照组,差异有统计学意义(U=2.51,P=0.02);治疗前两组患者FEV_1差异无统计学意义(P0.05),治疗后观察组患者FEV_1明显提高(P=0.03),对照组患者FEV_1轻度降低(P=0.90),观察组患者FEV_1明显优于对照组,差异有统计学意义(U=2.03,P=0.03);观察组患者人均总治疗费用明显低于对照组,差异有统计学意义(F=1872.48,P0.01)。结论应用雾霾防护措施可以明显降低CODP患者AECOPD发生率,改善患者肺功能状况,同时降低患者的平均治疗费用,值得临床推广应用。
[Abstract]:Objective to observe the effect of prevention of haze in Shijiazhuang area against acute exacerbation of chronic obstructive pulmonary disease (CODP). Methods from January 2013 to August 2015, 140 patients with COPD were randomly divided into observation group and control group. The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with PM2.5 mask, air purifier and other haze protective measures on the basis of the patients in the control group. The incidence of acute exacerbation of COPD, the changes of pulmonary function and the cost of treatment were observed and compared between the two groups to evaluate the therapeutic effect of the two groups. Results Sixty-four patients in the observation group and 68 patients in the control group completed the study, and the average number of AECOPD attacks in the observation group was significantly lower than that in the control group (P 0.01). There was no significant difference in FEV_1/FVC between the two groups before treatment (P0.05). After treatment, the FEV_1/FVC in the observation group was significantly increased (P0.01), and the FEV_1/FVC in the control group was slightly decreased (P0. 86). The FEV_1/FVC in the observation group was significantly better than that in the control group, and the difference was statistically significant (U2.51 P0. 02). There was no significant difference in FEV_1 between the two groups before treatment (P0.05). After treatment, the FEV_1 of the patients in the observation group increased significantly (P0. 03), and the FEV_1 in the control group decreased slightly (P0. 90). The FEV_1 of the observation group was significantly better than that of the control group, and the difference was statistically significant (U2.03% P0. 03). The total treatment cost per capita in the observation group was significantly lower than that in the control group (F _ (1872. 48) P _ (0.01). Conclusion the application of haze can significantly reduce the incidence of AECOPD in patients with CODP, improve the pulmonary function of the patients, and reduce the average cost of treatment, which is worthy of clinical application.
【作者单位】：河北省中医院骨科;河北省胸科医院呼吸内科;河北省中医院呼吸一科;
【分类号】：R563.9

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