P38-MK2-HuR通路在急性呼吸窘迫综合征炎症因子表达中的作用
发布时间:2018-11-08 07:44
【摘要】:正急性呼吸窘迫综合征(ARDS)是常见的临床危重症,是多器官功能障碍最常出现的器官损伤。目前认为ARDS是失控的全身炎症反应导致的非心源性肺水肿,感染、创伤和胰腺炎等多种原因可引起ARDS。其中,感染仍是ARDS最常见的原因。临床上ARDS的病死率很高,而有效的治疗方法仍旧缺乏。因此,需要深入研究ARDS发生发展的病理生理改变,阐明ARDS重要促炎因子表达调控机
[Abstract]:Positive acute respiratory distress syndrome (ARDS) is a common clinical critical disease, and it is the most common organ injury with multiple organ dysfunction. It is believed that ARDS is a non-cardiogenic pulmonary edema caused by uncontrolled systemic inflammatory reaction, infection, trauma and pancreatitis can lead to ARDS.. Infection is still the most common cause of ARDS. Clinical mortality of ARDS is high, but effective treatment is still lacking. Therefore, it is necessary to study the pathophysiological changes of ARDS and clarify the important pro-inflammatory factor expression and regulation mechanism of ARDS.
【作者单位】: 南方医科大学附属金陵医院(南京军区南京总医院)呼吸内科;南京大学附属金陵医院(南京军区南京总医院)呼吸内科;
【基金】:国家自然科学基金(81270138);国家自然科学基金(81670073) 国家科技支撑计划课题子课题(2015BAI12B00) 江苏省自然科学基金(BK20161383)
【分类号】:R563.8
,
本文编号:2317831
[Abstract]:Positive acute respiratory distress syndrome (ARDS) is a common clinical critical disease, and it is the most common organ injury with multiple organ dysfunction. It is believed that ARDS is a non-cardiogenic pulmonary edema caused by uncontrolled systemic inflammatory reaction, infection, trauma and pancreatitis can lead to ARDS.. Infection is still the most common cause of ARDS. Clinical mortality of ARDS is high, but effective treatment is still lacking. Therefore, it is necessary to study the pathophysiological changes of ARDS and clarify the important pro-inflammatory factor expression and regulation mechanism of ARDS.
【作者单位】: 南方医科大学附属金陵医院(南京军区南京总医院)呼吸内科;南京大学附属金陵医院(南京军区南京总医院)呼吸内科;
【基金】:国家自然科学基金(81270138);国家自然科学基金(81670073) 国家科技支撑计划课题子课题(2015BAI12B00) 江苏省自然科学基金(BK20161383)
【分类号】:R563.8
,
本文编号:2317831
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