通过脉冲震荡系统评价COPD的呼吸阻抗

发布时间：2018-11-08 18:56

【摘要】：目的脉冲震荡可评估肺阻力和电抗,我们的目的是去研究COPD中哪一个IOS参数与气道阻力、小气道功能和残气量相关。方法 180例COPD患者入组,95例随访1年。IOS参数(R5、R20、X5、Fres),肺体描记法(FEF75、TLC、RV、Rtot)和肺量计法(FEV1)被测量。Pearson和Spearman相关法评价IOS和其他测量法的关系。结果 R5、X5、Fres与FEV1、FEF75、RV、Rtot显著相关,而R20除与FEF75、Rtot低度相关(相关系数小于0.25)外,与其他参数均无相关性。1年后,FEV1、X5较前增大,RV减小,差异均有显著性。其他参数1年前后差异无显著性。FEV1、RV1年前后的变化值与R5、X5、Fres的变化值相关,而与R20的变化值不相关。结论 IOS电抗值X5比阻力值与COPD其他肺功能参数关系更密切。IOS电抗参数对于气流阻塞引起的肺顺应性的改变具有指示作用。
[Abstract]:Objective to evaluate pulmonary resistance and reactance by pulse oscillation. Our aim is to study which IOS parameters in COPD are related to airway resistance, small airway function and residual volume. Methods patients with COPD were enrolled and 95 patients were followed up for one year. The parameters of IOS (R5N R20X5Fres), pulmonary tracheography (FEF75,TLC,RV,Rtot) and pulmonary meter method (FEV1) were measured. Pearson and Spearman correlation methods were used to evaluate the relationship between IOS and other measurement methods. Results there was a significant correlation between R5 and FEV1,FEF75,RV,Rtot, but R20 had no correlation with other parameters except FEF75,Rtot (correlation coefficient < 0. 25). After 1 year, FEV1,X5 increased and RV decreased. The difference was significant. There was no significant difference between the other parameters before and after one year, but the change value of FEV1,RV1 year was correlated with the change value of R5X5Fres, but not with the change value of R20. Conclusion the IOS reactance value X5 is more closely related to other pulmonary function parameters of COPD than the resistance value. IOS reactance parameter can indicate the change of lung compliance caused by airflow obstruction.
【作者单位】：同济大学附属上海市肺科医院肺功能室;
【分类号】：R563.9

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