北京市颗粒物污染对慢性阻塞性肺疾病急性加重住院的影响
发布时间：2018-11-16 13:30
【摘要】：目的:研究北京市颗粒物污染对慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的影响,并分析颗粒物污染对不同特征人群的影响差异。方法:从国家卫生与计划生育委员会医疗管理服务指导中心获取北京市2014年至2015年三甲医院AECOPD患者的住院资料,从中国空气质量监测平台获取同期大气污染资料,从中国气象局获取同期气象资料。采用广义相加Poisson回归模型,在控制长期趋势、周效应、节假日效应、气象条件等混杂因素后,评估PM_(2.5)、PM_(10)对AECOPD住院人次的影响。根据患者不同特征(性别、年龄)进行亚组分析,确定颗粒物污染的高危人群。结果:纳入15家医院,共7 884例住院患者,男女比例2.3∶1,65~79岁患者最多(45.5%)、≥80岁(37.1%)次之、65岁(17.4%)最少。PM_(2.5)、PM_(10)日均浓度分别为(77.1±66.6)μg/m~3、(111.9±75.8)μg/m~3,两者均在移动平均滞后4 d时对AECOPD的影响最大,即PM_(2.5)日均浓度每增加10μg/m~3,AECOPD住院人次增加0.53%(95%CI:0.01%~1.06%,P=0.0478),PM_(10)日均浓度每增加10μg/m~3,AECOPD住院人次增加0.53%(95%CI:0.07%~1.00%,P=0.025 0)。亚组分析结果显示,PM_(2.5)、PM_(10)日均浓度每增加10μg/m~3,女性患者住院人次分别增加1.13%(95%CI:0.19%~2.07%,P=0.018 3)、1.06%(95%CI:0.22%~1.91%,P=0.013 6);≥80岁患者住院人次分别增加1.25%(95%CI:0.40%~2.11%,P=0.004 0)、1.18%(95%CI:0.42%~1.95%,P=0.002 4);而男性、65岁、65~79岁患者中,PM_(2.5)、PM_(10)与AECOPD的关联无统计学意义。由此可见,女性、≥80岁患者对颗粒物污染更敏感。结论:颗粒物污染会增加AECOPD住院风险,且女性、年老者风险更高。
[Abstract]:Aim: to study the effect of particulate pollution on acute exacerbation of chronic obstructive pulmonary disease (acute exacerbation of chronic obstructive pulmonary disease,AECOPD) in Beijing, and to analyze the effect of particulate pollution on different characteristic population. Methods: the hospitalization data of AECOPD patients in the third Class A Hospital of Beijing from 2014 to 2015 were obtained from the Medical Management Service guidance Center of the National Health and Family Planning Commission, and the air pollution data of the same period were obtained from the China Air quality Monitoring platform. Obtain meteorological data for the same period from the China Meteorological Administration. A generalized additive Poisson regression model was used to evaluate the effects of PM_ (2.5) and PM_ (10) on AECOPD hospitalizations after controlling the long-term trend, week effect, holiday effect and meteorological conditions. Subgroup analysis was carried out according to different characteristics of patients (sex and age) to determine the high risk population for particulate pollution. Results: a total of 7 884 inpatients were included in 15 hospitals. The male / female ratio of 2.3: 1 to 65% was the highest (45. 5%), followed by 鈮，
本文编号：2335640
[Abstract]:Aim: to study the effect of particulate pollution on acute exacerbation of chronic obstructive pulmonary disease (acute exacerbation of chronic obstructive pulmonary disease,AECOPD) in Beijing, and to analyze the effect of particulate pollution on different characteristic population. Methods: the hospitalization data of AECOPD patients in the third Class A Hospital of Beijing from 2014 to 2015 were obtained from the Medical Management Service guidance Center of the National Health and Family Planning Commission, and the air pollution data of the same period were obtained from the China Air quality Monitoring platform. Obtain meteorological data for the same period from the China Meteorological Administration. A generalized additive Poisson regression model was used to evaluate the effects of PM_ (2.5) and PM_ (10) on AECOPD hospitalizations after controlling the long-term trend, week effect, holiday effect and meteorological conditions. Subgroup analysis was carried out according to different characteristics of patients (sex and age) to determine the high risk population for particulate pollution. Results: a total of 7 884 inpatients were included in 15 hospitals. The male / female ratio of 2.3: 1 to 65% was the highest (45. 5%), followed by 鈮，
本文编号：2335640
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