血浆合肽素水平在慢性阻塞性肺疾病急性加重期中的临床意义

发布时间：2018-11-20 17:01

【摘要】：目的探讨血浆合肽素在慢性阻塞性肺疾病(简称慢阻肺)急性加重期中的临床意义。方法选取2013年10月至2015年11月在我院呼吸科收治的慢阻肺急性加重患者90例作为慢阻肺急性加重组,同期查体健康者40例作为对照组。采用酶联免疫吸附法检测血浆合肽素水平。比较慢阻肺急性加重患者治疗前后合肽素、白细胞计数(WBC)、C反应蛋白(CRP)的变化。分析慢阻肺急性加重组血浆合肽素水平与病情严重程度的相关性。结果慢阻肺急性加重组血浆合肽素明显高于对照组[(16.4±5.2)pmol/L vs.(5.7±2.8)pmol/L,P0.05],且随病情加重逐渐升高。慢阻肺急性加重患者治疗前、后血浆合肽素水平与血浆CRP、外周血白细胞总数呈正相关(P0.05)。结论血浆合肽素水平与慢阻肺急性加重病情程度相关,合肽素水平可作为慢阻肺急性加重患者病情严重程度的一种观察指标。
[Abstract]:Objective to investigate the clinical significance of plasma synpeptide in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods from October 2013 to November 2015, 90 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) admitted in our hospital from October 2013 to November 2015 were selected as acute COPD plus reorganization, and 40 healthy patients as control group. The plasma levels of synpeptidin were detected by Elisa. To compare the changes of (WBC), C reactive protein (CRP) in plasma and leukocyte count before and after treatment in patients with acute exacerbation of COPD. To analyze the relationship between the level of plasma plasmapeptide and severity of chronic obstructive pulmonary disease (COPD). Results compared with the control group, the level of plasma plasmapeptide in acute COPD group was significantly higher than that in the control group [(16.4 卤5.2) pmol/L vs. (5.7 卤2.8) pmol/L,P0.05], and increased gradually with the exacerbation of the disease. Before and after treatment in patients with acute exacerbation of COPD, there was a positive correlation between plasma levels of synpeptidin and the total number of peripheral white blood cells in plasma CRP, (P0.05). Conclusion the plasma level of synpeptidin is correlated with the severity of acute exacerbation of COPD, and it can be used as an index of the severity of acute exacerbation of COPD.
【作者单位】：南京市胸科医院内镜中心;
【分类号】：R563.9

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