慢性阻塞性肺疾病与动脉粥样硬化的相关性研究

发布时间：2018-11-21 13:11

【摘要】：目的：探讨慢性阻塞性肺疾病（COPD）发生动脉粥样硬化的危险因素，为COPD患者心血管疾病的有效预防提供理论依据。方法：本研究纳入130例COPD患者（COPD组）及131例健康体检者（对照组）。COPD组患者均行肺功能检查确诊。分别记录两组的吸烟指数，检测两组颈动脉内膜中层厚度（IMT），及斑块形成状况。检测空腹静脉血低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胆固醇(TC)、甘油三酯(TG)、同型半胱氨酸（HCY）、纤维蛋白原浓度（FIB）等指标。将COPD组内患者颈动脉IMT的相关因素作多元回归分析及pearson相关分析。结果：与对照组比较，COPD组IMT值、斑块检出率和吸烟指数均显著增高，而血中TC、LDL-C水平则低于健康组(P＜0.05)。pearson相关分析显示年龄、吸烟指数与COPD患者颈动脉IMT呈正相关，FEV1%与IMT呈负相关。多元回归分析显示年龄、FEV1%与COPD患者颈动脉IMT呈直线相关(P＜0.05)。结论：（1）年龄是COPD患者动脉粥样硬化的危险因素，但COPD疾病本身可加重动脉粥样硬化的程度。（2）吸烟指数可能是动脉狭窄的危险因素之一。（3）颈动脉IMT与FEV1%呈直线负相关关系。（4）COPD患者血清LDL-C、TC水平较低，但与动脉粥样硬化并不直接相关。
[Abstract]:Objective: to explore the risk factors of atherosclerosis in patients with chronic obstructive pulmonary disease (COPD) and to provide theoretical basis for the effective prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD). Methods: 130 patients with COPD (COPD group) and 131 healthy controls (control group). COPD group) were diagnosed by pulmonary function test. Smoking index was recorded and carotid intima-media thickness (IMT),) and plaque formation were measured. Fasting venous low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and cholesterol (TC), triglyceride (TG), homocysteine (HCY), fibrinogen (FIB) were measured. The factors related to carotid IMT in COPD group were analyzed by multiple regression analysis and pearson correlation analysis. Results: compared with the control group, the IMT value, plaque detection rate and smoking index in COPD group were significantly higher, while the level of TC,LDL-C in blood was lower than that in healthy group (P < 0. 05). Pearson correlation analysis showed age). Smoking index was positively correlated with carotid IMT, and FEV1% was negatively correlated with IMT in patients with COPD. Multiple regression analysis showed that there was a linear correlation between FEV1% and carotid IMT in patients with COPD (P < 0. 05). Conclusion: (1) Age is a risk factor for atherosclerosis in COPD patients, but COPD disease itself can aggravate the degree of atherosclerosis. (2) smoking index may be one of the risk factors of arterial stenosis. (3) there was a linear negative correlation between carotid IMT and FEV1%. (4) the serum LDL-C,TC level was lower in COPD patients, but not directly related to atherosclerosis.
【学位授予单位】：川北医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.9

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