乌司他丁预防急性呼吸窘迫综合征发生的作用
发布时间：2018-11-26 07:04
【摘要】：目的探讨乌司他丁在急性呼吸窘迫综合征(ARDS)发生中的预防作用。方法具有ARDS发生风险的患者59例,采用随机数字表法分为观察组和对照组,观察组在基础治疗的基础上加用乌司他丁治疗。观察连续用药7 d后两组患者的血气指标变化情况、C反应蛋白(CRP)、白细胞介素(IL)-6及肿瘤坏死因子(TNF)-α表达水平,比较两组患者ICU入住时间、机械通气时间及28 d生存率、急性生理和慢性健康状态(APACHE)Ⅱ评分及ARDS发生率。结果治疗后,两组患者血气指标(pH、PaO_2、PaCO_2、PaO_2/FiO_2)均较治疗前升高,且观察组PaO_2、PaO_2/FiO_2均高于对照组(P0.05);两组患者TNF-α、IL-6、CRP均较治疗前降低,且观察组均低于对照组(P0.05)。治疗后,观察组APACHEⅡ评分、机械通气时间和ICU入住时间均明显低于对照组(P0.05)。观察组ARDS发生率为10.00%,显著低于对照组ARDS发生率34.48%(P0.05);两组患者28 d生存率的差异无统计学意义(P0.05)。结论乌司他丁在改善重症患者血气指标、降低炎症反应、提高临床疗效、降低ARDS发生风险等方面具有显著的作用。
[Abstract]:Objective to investigate the preventive effect of ulinastatin on acute respiratory distress syndrome (ARDS). Methods 59 patients with risk of ARDS were randomly divided into observation group and control group. The observation group was treated with ulinastatin on the basis of basic treatment. The changes of blood gas index, the expression of C-reactive protein (CRP), interleukin (IL) 6 and tumor necrosis factor (TNF) 伪 were observed in the two groups after 7 days of continuous administration. The time of ICU stay in the two groups was compared. Mechanical ventilation time and 28 day survival rate, acute physiological and chronic health state (APACHE) 鈪，
本文编号：2357716
[Abstract]:Objective to investigate the preventive effect of ulinastatin on acute respiratory distress syndrome (ARDS). Methods 59 patients with risk of ARDS were randomly divided into observation group and control group. The observation group was treated with ulinastatin on the basis of basic treatment. The changes of blood gas index, the expression of C-reactive protein (CRP), interleukin (IL) 6 and tumor necrosis factor (TNF) 伪 were observed in the two groups after 7 days of continuous administration. The time of ICU stay in the two groups was compared. Mechanical ventilation time and 28 day survival rate, acute physiological and chronic health state (APACHE) 鈪，
本文编号：2357716
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