α2巨球蛋白在老年肺结核患者外周血中的表达及临床意义

发布时间：2018-11-29 09:00

【摘要】：目的探讨α2巨球蛋白(α2MG)在老年肺结核患者外周血浆中的表达水平及其对临床诊断与治疗的指导意义。方法收集60岁以上住院肺结核患者34例在抗结核治疗前后的外周血,并收集18例健康对照的外周血,酶联免疫吸附(ELISA)法检测血浆中α2MG和C反应蛋白(CRP)的浓度,并检测血沉时间。结果老年结合患者外周血中α2MG的水平明显高于健康老年人(P0.01),α2MG浓度为1.61 mg/L,可作为诊断老年肺结核的切点(cut-off)值,其敏感性和特异性分别为85.3%和77.8%。经规律抗结核治疗后老年肺结核患者的血浆α2MG表达水平明显升高(P0.05),且其表达与血浆CRP水平和血沉呈负相关。结论患肺结核后老年人外周血中α2MG表达上调,并可作为诊断和检测结合治疗的生物学标志物。
[Abstract]:Objective to investigate the expression of 伪 2 macroglobulin (伪 2MG) in peripheral plasma of elderly patients with pulmonary tuberculosis and its significance in clinical diagnosis and treatment. Methods the peripheral blood of 34 patients over 60 years old with pulmonary tuberculosis before and after anti-tuberculosis treatment and 18 healthy controls were collected. The concentrations of 伪 2MG and C-reactive protein (CRP) in plasma were detected by enzyme-linked immunosorbent assay (ELISA). ESR time was measured. Results the level of 伪 2MG in peripheral blood of elderly patients with pulmonary tuberculosis was significantly higher than that of healthy elderly patients (P0.01). The 伪 2MG concentration of 1.61 mg/L, could be used as the cut-off value for the diagnosis of senile pulmonary tuberculosis. The sensitivity and specificity were 85.3% and 77.8%, respectively. After regular anti-tuberculosis treatment, the expression of plasma 伪 2MG in elderly pulmonary tuberculosis patients increased significantly (P0.05), and its expression was negatively correlated with plasma CRP level and erythrocyte sedimentation rate (ESR). Conclusion the expression of 伪 2MG in peripheral blood of elderly patients with pulmonary tuberculosis is up-regulated and can be used as a biomarker for diagnosis and detection of combined therapy.
【作者单位】：淄博市第一医院感染性疾病科;吉林大学白求恩第一医院呼吸科;吉林大学白求恩第一医院干部病房;
【基金】：吉林省科技厅资助项目(No.20130413030GH)
【分类号】：R521

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