多索茶碱联合雾化吸入治疗对慢性阻塞性肺疾病患者血清IL-8水平及肺功能影响的研究

发布时间：2018-12-15 14:05

【摘要】：目的:探讨慢性阻塞性肺疾病患者通过雾化吸入和多索茶碱联合雾化吸入药物治疗前、后血清IL-8水平、肺功能及血气分析等相关指标的变化程度及关系,为临床合理用药提供更可靠循证医学的依据。方法:选取我院呼吸科住院治疗的明确诊断为慢性阻塞性肺疾病C、D组的患者共60例,随机分为两组,每组各30例。其中,多索茶碱联合雾化吸入药物组为联合药物组;雾化吸入药物组为单纯药物组;两组另外均给予氧疗、抗感染、化痰等治疗,两组治疗疗程均为10天;对两组患者治疗前及治疗后第10天。采用ELISA法测定IL-8浓度,并与肺功能及血气分析指标进行相关性比较,最后统计分析检测得出数据。结果:1、两组患者血清炎性因子IL-8水平治疗后较治疗前均下降,有统计学意义(P0.05);治疗后联合药物组与单纯药物组相比较炎症因子水平降低更为显著,差异有统计学意义(P0.05)。2、两组患者治疗后的肺功能指标(FEV1%pred、FVC%pred、PEF%pred、MMEF%pred)较治疗前均有提高(P0.05);治疗后联合药物组与单纯药物组相比较肺功能改善更为显著,差异有统计学意义(P0.05)。3、两组患者治疗后的血气分析指标(Pa O_2、Sa O_2、Pa CO_2)较治疗前比较均有改善(P0.05);治疗后的联合药物组与对单纯药物组相比较血气分析改善更为显著,差异有统计学意义(P0.05)。4.两组患者治疗前后血清IL-8与Pa CO_2呈正相关,与FEV1%pred、FVC%pred、PEF%pred、MMEF%pred、Pa O_2、Sa O_2呈负相关(P0.05)。结论:1、慢性阻塞性肺疾病患者随着炎症的控制,血清IL-8水平降低。2、多索茶碱联合雾化吸入治疗可明显降低炎症因子IL-8水平,改善气流受限,纠正低氧。3、患者血清IL-8升高,说明炎症因子IL-8参与了慢性阻塞性肺疾病患者的气道炎症过程,并与肺功能受损有关。
[Abstract]:Objective: to investigate the changes of serum IL-8 level, pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease (COPD) before and after treatment with aerosol inhalation and doxofylline combined atomization inhalation. To provide a more reliable evidence-based medicine for rational use of drugs. Methods: a total of 60 patients with chronic obstructive pulmonary disease (COPD) were randomly divided into two groups (30 cases in each group). Among them, doxophylline combined with aerosol inhalation group was the combined drug group, the atomization inhaled drug group was simple drug group, the two groups were also given oxygen therapy, anti-infection, phlegm treatment, the two groups were treated for 10 days. Patients in both groups were treated before and 10 days after treatment. The concentration of IL-8 was measured by ELISA method, and compared with pulmonary function and blood gas analysis. Finally, the data were obtained by statistical analysis. Results: 1. The level of serum inflammatory factor IL-8 decreased after treatment in both groups (P0.05). After treatment, the level of inflammatory cytokines in the combined drug group was significantly lower than that in the simple drug group (P0.05). 2. The pulmonary function index (FEV1%pred,FVC%pred,PEF%pred,) of the two groups after treatment was significantly lower than that in the control group (P0.05). MMEF%pred) was higher than that before treatment (P0.05). The improvement of pulmonary function in the combined drug group was more significant than that in the simple drug group after treatment (P0.05). 3. The blood gas analysis index of the two groups after treatment (Pa O2Sa O 2, P < 0.05). Pa CO_2) were improved compared with those before treatment (P0.05). After treatment, the blood gas analysis in the combined drug group was more significant than that in the simple drug group, and the difference was statistically significant (P0.05). There was a positive correlation between serum IL-8 and Pa CO_2 before and after treatment, and a negative correlation between serum IL-8 and FEV1%pred,FVC%pred,PEF%pred,MMEF%pred,Pa O _ 2 sa _ O _ 2 (P0.05). Conclusion: 1. With the control of inflammation, serum IL-8 level decreased in patients with chronic obstructive pulmonary disease (COPD). 2. Doxophylline combined with atomization inhalation can significantly reduce the level of inflammatory factor IL-8, improve airflow limitation, and correct hypoxia. The increase of serum IL-8 suggests that the inflammatory factor IL-8 is involved in the airway inflammation in patients with chronic obstructive pulmonary disease and is related to the impairment of pulmonary function.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9

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