血清合肽素对呼吸衰竭患者预后评估的临床意义
发布时间：2018-12-21 16:24
【摘要】：目的探讨合肽素水平对呼吸衰竭患者预后的临床意义,以更好地开展治疗工作。方法选取2010年12月—2012年12月吉林省前卫医院呼吸科和吉林大学第一医院急诊科重症监护室收治的132例呼吸衰竭患者,检测患者入院时的血清合肽素水平,并记录各项实验室检测指标和临床生理指标。以28 d为终点比较存活组与死亡组患者的合肽素水平、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分和简化急性生理学评分系统Ⅱ(SAPSⅡ)评分;分析合肽素水平与28 d病死率的关系。结果 132例呼吸衰竭患者28 d内共有41例病死,死亡组血清合肽素水平高于存活组,差异有统计学意义〔(44.5±9.0)pmol/L比(29.2±12.0)pmol/L,P0.01〕。合肽素水平与APACHEⅡ评分和SAPSⅡ评分均呈正相关(r值分别为0.562、0.550)。合肽素水平预测28 d病死率的受试者工作特征曲线(ROC曲线)下面积为0.840〔95%CI(0.772,0.907)〕,预测28 d病死率的最佳界值为34.5 pmol/L。血清合肽素34.5 pmol/L、APACHEⅡ评分17.5分和SAPSⅡ评分30.5分是预测呼吸衰竭患者28 d病死率的独立危险因素。结论合肽素水平是预测呼吸衰竭患者28 d病死率的独立指标,其预测能力与APACHEⅡ评分和SAPSⅡ评分相近。
[Abstract]:Objective to investigate the clinical significance of peptide level in the prognosis of patients with respiratory failure. Methods from December 2010 to December 2012, 132 patients with respiratory failure were selected from Department of Respiratory, Department of Respiratory and Emergency Department, first Hospital of Jilin University. The laboratory indexes and clinical physiological indexes were recorded. At the end of 28 days, the levels of synpeptidin, acute physiology and chronic health status scoring system 鈪，
本文编号：2389154
[Abstract]:Objective to investigate the clinical significance of peptide level in the prognosis of patients with respiratory failure. Methods from December 2010 to December 2012, 132 patients with respiratory failure were selected from Department of Respiratory, Department of Respiratory and Emergency Department, first Hospital of Jilin University. The laboratory indexes and clinical physiological indexes were recorded. At the end of 28 days, the levels of synpeptidin, acute physiology and chronic health status scoring system 鈪，
本文编号：2389154
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