三亚市老年肺结核患者治疗失败的影响因素调查分析

发布时间：2018-12-30 11:38

【摘要】：目的探讨三亚市老年肺结核患者治愈失败的影响因素,为提高治疗效果提供依据。方法对确诊的895例老年肺结核患者进行回顾性调查,依据是否治愈分为治愈组(n=782)和治疗失败组(n=113),采用单因素比较分析和多因素logistic回归来筛选可能影响治疗失败的因素。结果老年肺结核患者治疗失败率为12.6%(113/895);多因素分析结果显示有合并症(OR=2.960)、有空洞(OR=4.102)、2个月末痰检阳性(OR=3.308)、不规则服药(OR=1.837)、耐药(OR=5.712)、未全程督导(OR=4.401)、未系统管理(OR=1.908)、2个月末痰检阳性×耐药(OR=2.445),这些因素均为老年肺结核治疗失败的危险因素。结论老年肺结核治疗失败率仍然较高,影响其治疗失败的独立危险因素包括伴随合并症、肺部有空洞、2个月末痰检阳性、不规则服药、耐药性、未全程督导及未系统化管理,2个月末痰检阳性与耐药性存在交互作用。
[Abstract]:Objective to explore the factors influencing the cure failure of senile pulmonary tuberculosis patients in Sanya city, and to provide evidence for improving the therapeutic effect. Methods A retrospective survey was conducted in 895 elderly patients with pulmonary tuberculosis. The patients were divided into two groups according to whether they were cured or not. The patients were divided into two groups: the cured group (nnt782) and the failed treatment group (nx113). Univariate comparative analysis and multivariate logistic regression were used to screen the factors that might affect treatment failure. Results the failure rate of treatment in elderly patients with pulmonary tuberculosis was 12.6% (113 / 895). Multivariate analysis showed complications (OR=2.960), cavities (OR=4.102), sputum positive (OR=3.308), irregular drug taking (OR=1.837), drug resistance (OR=5.712), and OR=4.401 at the end of 2 months. Unsystematic management (OR=1.908) and sputum positive 脳 drug resistance (OR=2.445) at the end of 2 months were all risk factors for the failure of treatment of senile pulmonary tuberculosis. Conclusion the failure rate of treatment for elderly patients with pulmonary tuberculosis is still high. The independent risk factors affecting the treatment failure include accompanying complications, pulmonary cavity, positive sputum examination at the end of 2 months, irregular medication, drug resistance, incomplete supervision and unsystematic management. There was interaction between sputum positive and drug resistance at the end of 2 months.
【作者单位】：海南省三亚市疾病预防控制中心结核病防治所;
【基金】：海南省科技厅项目(KX2013003)
【分类号】：R521

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