核转录因子Nrf2与肺部炎症疾病研究进展
发布时间：2019-01-08 17:51
【摘要】：核因子NF-E2相关因子(nuclear factor erythroid 2-related factor 2,Nrf2)是氧化应激反应敏感基因的重要转录因子之一,可调节依赖抗氧化反应元件(antioxidant response elements,ARE)的多种抗氧化蛋白的生成。研究显示,Nrf2-Keap1(Kelch样ECH联合蛋白1)-ARE信号通路是细胞内重要的内源性抗氧化防御机制之一,上调该信号通路可诱导其下游调控的多种抗氧化酶及解毒酶,提高谷胱甘肽及超氧化物歧化酶等抗氧化物质的表达水平,清除自由基,维持细胞内氧化还原平衡状态,发挥内源性细胞保护作用。近年来,大气污染尤其PM2.5可能是导致呼吸道炎症发病率升高以及炎症加重的关键因素之一,Nrf2及其信号通路对气道炎症性疾病如支气管哮喘、慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)和急性肺损伤(acute lung injury,ALI)的调控,有望成为防治肺部炎症性疾病药物研究潜在性靶点。本文就Nrf2与气道炎症和氧化应激相关信号通路调控进行综述。
[Abstract]:Nuclear factor NF-E2 related factor (nuclear factor erythroid 2-related factor 2n rf2 is one of the important transcription factors of oxidative stress response sensitive genes. It can regulate the production of many antioxidant proteins which depend on the antioxidant response element (antioxidant response elements,ARE). It has been shown that Nrf2-Keap1 (Kelch like ECH Associated protein 1)-ARE signaling pathway is one of the important endogenous antioxidant defense mechanisms in cells, and up-regulation of the signaling pathway can induce a variety of antioxidant enzymes and detoxifying enzymes regulated downstream. To improve the expression level of glutathione and superoxide dismutase (SOD), scavenge free radicals, maintain redox equilibrium in cells, and play an endogenous role in cell protection. In recent years, air pollution, especially PM2.5, may be one of the key factors leading to the increase of respiratory inflammation and the exacerbation of inflammation. Nrf2 and its signaling pathway play an important role in airway inflammatory diseases such as bronchial asthma. The regulation of chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) and acute lung injury (acute lung injury,ALI) is expected to be a potential target for drug research in the prevention and treatment of pulmonary inflammatory diseases. This review reviews the regulation of Nrf2 and airway inflammation and oxidative stress related signaling pathways.
【作者单位】： 中国医学科学院、北京协和医学院药物研究所、天然药物活性物质与功能国家重点实验室;
【基金】：天然活性物质与功能国家重点实验室开放课题资助项目(GTZK201407) 国家自然科学基金资助项目(80473398) 十二五综合大平台-药效学评价资助项目(2012ZX09301002001002)
【分类号】：R563
[Abstract]:Nuclear factor NF-E2 related factor (nuclear factor erythroid 2-related factor 2n rf2 is one of the important transcription factors of oxidative stress response sensitive genes. It can regulate the production of many antioxidant proteins which depend on the antioxidant response element (antioxidant response elements,ARE). It has been shown that Nrf2-Keap1 (Kelch like ECH Associated protein 1)-ARE signaling pathway is one of the important endogenous antioxidant defense mechanisms in cells, and up-regulation of the signaling pathway can induce a variety of antioxidant enzymes and detoxifying enzymes regulated downstream. To improve the expression level of glutathione and superoxide dismutase (SOD), scavenge free radicals, maintain redox equilibrium in cells, and play an endogenous role in cell protection. In recent years, air pollution, especially PM2.5, may be one of the key factors leading to the increase of respiratory inflammation and the exacerbation of inflammation. Nrf2 and its signaling pathway play an important role in airway inflammatory diseases such as bronchial asthma. The regulation of chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) and acute lung injury (acute lung injury,ALI) is expected to be a potential target for drug research in the prevention and treatment of pulmonary inflammatory diseases. This review reviews the regulation of Nrf2 and airway inflammation and oxidative stress related signaling pathways.
【作者单位】： 中国医学科学院、北京协和医学院药物研究所、天然药物活性物质与功能国家重点实验室;
【基金】：天然活性物质与功能国家重点实验室开放课题资助项目(GTZK201407) 国家自然科学基金资助项目(80473398) 十二五综合大平台-药效学评价资助项目(2012ZX09301002001002)
【分类号】：R563
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【共引文献】
相关期刊论文 前10条
1 张亮;杜佳;周立为;程q，
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