气流受限不完全可逆的慢性阻塞性肺疾病患者容量和流速变化与肺通气功能障碍严重程度分级的关系

发布时间：2019-01-16 03:24

【摘要】：目的探讨气流受限不完全可逆的慢性阻塞性肺疾病(COPD)在支气管舒张试验前后容量和流速变化与肺通气功能障碍严重程度的关系,并对COPD肺通气功能障碍严重程度分级的依据进行初步探索。方法收集2012年1月至2015年6月在中国医科大学附属盛京医院肺功能室登记的COPD患者447例,其中男254例,女193例,平均年龄(65±12)岁。气流受限不完全可逆定义为支气管舒张试验前后FEV1差值200 m L或FEV1改善率12%,尽量排除气道高反应性对本研究的影响。结果随着COPD肺通气功能障碍严重程度的增加,FEV1改变值逐渐变小,FVC改变率越来越大,FEV1改变率和FVC改变值没有呈现出具有统计学意义的规律变化。结论气流受限不完全可逆患者肺通气功能障碍严重程度越高,气流受限越来越不可逆;FEV1改变值可以作为评估COPD患者肺通气功能障碍严重程度分级是否合理的依据,分为3组可能是合理的。
[Abstract]:Objective to investigate the relationship between the changes of volume and velocity before and after bronchodiastolic test and the severity of pulmonary ventilation dysfunction in (COPD) with airflow limitation and non-reversible chronic obstructive pulmonary disease (COPD). At the same time, the basis of severity classification of COPD pulmonary ventilation dysfunction was preliminarily explored. Methods from January 2012 to June 2015, 447 patients with COPD were enrolled in lung function room of Shengjing Hospital affiliated to China Medical University, including 254 males and 193 females, with an average age of (65 卤12) years. The incomplete reversible airflow limitation was defined as the FEV1 difference of 200ml or FEV1 improvement rate of 12ml before and after bronchodiastolic test. The effect of airway hyperresponsiveness on this study was excluded as far as possible. Results with the increase of the severity of pulmonary ventilation dysfunction in COPD, the change value of FEV1 became smaller and the change rate of FVC became larger and larger. The change rate of FEV1 and FVC did not show statistical significance. Conclusion the more severe the degree of pulmonary ventilation dysfunction, the more irreversible the airflow limitation in patients with incomplete reversible airflow limitation. FEV1 changes can be used as a basis for evaluating the severity of pulmonary ventilation dysfunction in patients with COPD, and it may be reasonable to divide them into 3 groups.
【作者单位】：中国医科大学附属盛京医院呼吸内科;
【基金】：高等学校博士学科点专项科研基金(20122104110012)
【分类号】：R563.9

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