哮喘患者血常规、血清总IgE及支气管激发试验分析

发布时间：2019-01-21 08:24

【摘要】：目的通过对65例确诊支气管哮喘患者的血常规、血清总IgE及支气管激发试验阳性所用乙酰甲胆碱(MCH)剂量进行分析,以了解不同类型哮喘患者的气道阻力和气道反应性。方法选取于2012年6月至2013年6月在长沙市中心医院呼吸内科门诊就诊或住院的资料齐全的65例支气管哮喘患者。按血常规中嗜酸粒细胞比值是否升高,将65例支气管哮喘患者分为血嗜酸粒细胞增高组和血嗜酸粒细胞无增高组,两组分别为19例和46例。然后对不同组哮喘患者血清总IgE、气道阻力和支气管激发试验阳性所用MCH剂量进行对比分析。结果血嗜酸粒细胞增高组中,血清总IgE增高者(15例)和气道阻力增高者(16例)均高于血嗜酸粒细胞无增高组[(21例)和(27例)],差异均具有统计学意义(P0.05)。血嗜酸粒细胞增高组激发试验阳性所用的MCH剂量[(1.15±0.75)mg]明显低于血嗜酸粒细胞无增高组[(1.67±0.69)mg],差异具有显著统计学意义(P0.01)。结论血嗜酸粒细胞增高哮喘多为IgE介导的哮喘,此类哮喘较血嗜酸粒细胞无增高哮喘患者气道阻力高,气道反应性亦高。
[Abstract]:Objective to study the airway resistance and airway reactivity of 65 patients with asthma by analyzing the blood routine, total serum IgE and methacholine (MCH) dose used in bronchial provocation test. Methods from June 2012 to June 2013, 65 patients with bronchial asthma were enrolled in the Department of Respiratory Medicine, Changsha Central Hospital. 65 patients with bronchial asthma were divided into two groups according to whether the ratio of eosinophil increased in blood routine was increased or not. The two groups were divided into two groups: 19 cases and 46 cases, respectively, with elevated eosinophil in blood and no increase in eosinophil in blood. Then the serum total IgE, airway resistance and the dose of MCH used in bronchial provocation test were compared and analyzed in different groups of asthmatic patients. Results the patients with elevated serum total IgE (15 cases) and airway resistance (16 cases) were significantly higher than those without elevated eosinophil (21 cases) and (27 cases). The difference was statistically significant (P0.05). The dose of MCH in the high eosinophil group [(1.15 卤0.75) mg] was significantly lower than that in the no elevated eosinophil group [(1.67 卤0.69) mg], and the difference was statistically significant (P0.01). Conclusion Asthma with elevated eosinophils is mostly IgE mediated asthma. The airway resistance and airway responsiveness of these asthma patients are higher than those of patients without elevated eosinophils.
【作者单位】：长沙市中心医院呼吸内科;
【分类号】：R562.25

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