扶肺固肾膏对慢性阻塞性肺疾病稳定期患者BODE指数的影响

发布时间：2019-02-20 08:14

【摘要】：目的:研究扶肺固肾膏对慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期肺肾气阴两虚痰淤证BODE指数的影响,评价扶肺固肾膏治疗COPD的疗效。方法:按照课题设计的纳入和排除标准,收集60例符合COPD诊断的稳定期患者,随机平均分为两组,对照组和治疗组,对照组(舒利迭组)和治疗组(舒利迭加扶肺固肾膏组),对照组予舒利迭治疗,治疗组在对照组治疗基础上口服扶肺固肾膏,疗程3个月。治疗前后分别测试两组患者的BODE指数,将所有数据建立数据库,运用统计软件进行分析,对比两组患者治疗前后BODE指数各个变量及BODE总分的改变。结果:1、两组患者治疗前后比较:两组患者治疗后与治疗前相比,第一秒用力呼气容积占预计值百分比(FEV1%pred)、6分钟步行距离(6MWD)均明显增加,差异有统计学意义(P0.05),呼吸困难问卷(mMRC)、BODE指数评分较治疗前明显下降,差异有统计学意义(P0.05),两组患者体质指数(BMI)在治疗前后差异无统计学意义(P0.05)。2、两组患者治疗后组间比较:两组患者经治疗后,治疗组的FEV1%pred、6MWD升高较对照组明显,差异有统计学意义(P0.05),治疗组的mMRC、BODE指数评分下降较对照组明显,差异有统计学意义(P0.05)。结论:扶肺固肾膏配合吸入激素能明显提高COPD稳定期中医证型属肺肾气阴两虚痰淤证患者的FEV1%pred、6MWD,降低患者mMRC、BODE指数评分,临床上用药安全,值得推广使用。
[Abstract]:Objective: to study the effect of Fufei Gushen ointment on BODE index of stable lung and kidney qi and yin deficiency and phlegm stasis syndrome in patients with chronic obstructive pulmonary disease (Chronic obstructive pulmonary disease,COPD), and to evaluate the curative effect of Fu Fei Gu Shen ointment on COPD. Methods: according to the designed criteria of inclusion and exclusion, 60 stable patients diagnosed by COPD were randomly divided into two groups: control group and treatment group, control group (sulidide group) and treatment group (Sulidi plus Fufei Gushen ointment group). The control group was treated with sulidide, and the treatment group was treated with Fufei Gu Shen ointment for 3 months. The BODE index of two groups of patients was tested before and after treatment, and all the data were set up and analyzed by statistical software. The changes of BODE index and BODE total score before and after treatment were compared between the two groups. Results: 1. Comparison between the two groups before and after treatment: after treatment, forced expiratory volume in the first second (FEV1%pred) and 6-minute walking distance (6MWD) were significantly increased in both groups compared with those before treatment. The difference was statistically significant (P0.05). The (mMRC), BODE index score of dyspnea questionnaire was significantly lower than that before treatment (P0.05). There was no significant difference in body mass index (BMI) between the two groups before and after treatment (P0.05). The comparison between the two groups after treatment: after treatment, the FEV1%pred,6MWD in the treatment group was significantly higher than that in the control group. The difference was statistically significant (P0.05). The mMRC,BODE index score of the treatment group was significantly lower than that of the control group (P0.05). Conclusion: Fufei Gushen ointment combined with inhaled hormone can obviously improve the FEV1%pred,6MWD, of patients with stable COPD syndrome of lung and kidney qi and yin deficiency and phlegm stasis. It is safe to use drugs clinically and is worth popularizing.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9

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