血清IL-21、CXCL13水平与慢性阻塞性肺疾病的相关性研究
发布时间：2019-02-23 12:26
【摘要】：目的探讨患者血清中IL-21、CXCL13水平与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)不同疾病状态的相关性及其临床意义。方法收集20例健康非吸烟者、20例健康吸烟者、31例COPD稳定期患者和30例COPD急性加重期(acute exacerbation of COPD,AECOPD)患者的静脉血,经离心后取上清采用ELISA法检测血清中IL-21、CXCL13的水平,应用SPSS 21.0统计软件,采用单因素方差分析以及Pearson相关分析等方法,分析比较4组间IL-21、CXCL13水平的差异及相关性,并同时检测COPD稳定期组患者的肺功能及GOLD分级,分析肺功能、GOLD分级分别与IL-21、CXCL13水平的相关性。结果 AECOPD组患者血清中IL-21、CXCL13水平均明显高于COPD稳定期组、健康吸烟组、健康非吸烟组(P0.05);COPD稳定期组患者血清IL-21、CXCL13水平与健康吸烟组差异无统计学意义(P0.05),但明显高于健康非吸烟组(P0.05);健康吸烟组血清中IL-21、CXCL13水平显著高于健康非吸烟组(P0.05)。COPD稳定期组血清IL-21、CXCL13水平与患者肺功能中FEV1值呈负相关(r分别为-0.619、-0.505,P0.05),并与患者GOLD分级呈正相关(r分别为0.901、0.458,P0.05)。COPD稳定期患者血清中IL-21水平与CXCL13水平呈正相关(r=0.424,P0.05)。结论健康吸烟人群、COPD稳定期和急性加重期患者血清中IL-21、CXCL13水平显著上升;COPD稳定期患者血清中IL-21、CXCL13水平与肺功能和疾病严重程度相关;IL-21、CXCL13可能在COPD进程中发挥促炎作用。
[Abstract]:Objective to investigate the relationship between serum IL-21,CXCL13 level and different disease states of chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) and its clinical significance. Methods the venous blood samples from 20 healthy non-smokers, 20 healthy smokers, 31 stable COPD patients and 30 (acute exacerbation of COPD,AECOPD patients with acute exacerbation of COPD were collected. After centrifugation, the serum IL-21, was detected by ELISA method. The level of CXCL13 was analyzed and compared by using SPSS 21.0 software, single factor variance analysis and Pearson correlation analysis. At the same time, the pulmonary function and GOLD grade of COPD stable group were detected, and the correlation between pulmonary function and GOLD grade and IL-21,CXCL13 level were analyzed. Results the serum IL-21,CXCL13 levels in AECOPD group were significantly higher than those in stable COPD group, healthy smoking group and healthy non-smoking group (P0.05). There was no significant difference in serum IL-21,CXCL13 level between COPD stable group and healthy smoking group (P0.05), but it was significantly higher than that of healthy non-smoking group (P0.05). The level of serum IL-21,CXCL13 in the healthy smoking group was significantly higher than that in the healthy non-smoking group (P0.05). The serum IL-21,CXCL13 level in the stable). COPD group was negatively correlated with the value of FEV1 in the lung function of the patients (r = -0.619 ~ -0.505, respectively). There was a positive correlation between the serum IL-21 level and the CXCL13 level in the patients with stable). COPD (r = 0.901U 0.458P, respectively) (r = 0.424, P 0.05), and there was a positive correlation between the serum IL-21 level and the CXCL13 level (r = 0.901 / 0.458g, P < 0.05). Conclusion the serum IL-21,CXCL13 levels in healthy smokers, COPD stable and acute exacerbation patients were significantly increased, and the serum IL-21,CXCL13 levels were correlated with lung function and severity of disease in COPD stable patients. IL-21,CXCL13 may play an inflammatory role in the process of COPD.
【作者单位】： 第三军医大学新桥医院呼吸内科 全军呼吸内科研究所 全军呼吸病研究重点实验室;
【基金】：国家自然科学基金面上项目(81570051)~~
【分类号】：R563.9
，
本文编号：2428820
[Abstract]:Objective to investigate the relationship between serum IL-21,CXCL13 level and different disease states of chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD) and its clinical significance. Methods the venous blood samples from 20 healthy non-smokers, 20 healthy smokers, 31 stable COPD patients and 30 (acute exacerbation of COPD,AECOPD patients with acute exacerbation of COPD were collected. After centrifugation, the serum IL-21, was detected by ELISA method. The level of CXCL13 was analyzed and compared by using SPSS 21.0 software, single factor variance analysis and Pearson correlation analysis. At the same time, the pulmonary function and GOLD grade of COPD stable group were detected, and the correlation between pulmonary function and GOLD grade and IL-21,CXCL13 level were analyzed. Results the serum IL-21,CXCL13 levels in AECOPD group were significantly higher than those in stable COPD group, healthy smoking group and healthy non-smoking group (P0.05). There was no significant difference in serum IL-21,CXCL13 level between COPD stable group and healthy smoking group (P0.05), but it was significantly higher than that of healthy non-smoking group (P0.05). The level of serum IL-21,CXCL13 in the healthy smoking group was significantly higher than that in the healthy non-smoking group (P0.05). The serum IL-21,CXCL13 level in the stable). COPD group was negatively correlated with the value of FEV1 in the lung function of the patients (r = -0.619 ~ -0.505, respectively). There was a positive correlation between the serum IL-21 level and the CXCL13 level in the patients with stable). COPD (r = 0.901U 0.458P, respectively) (r = 0.424, P 0.05), and there was a positive correlation between the serum IL-21 level and the CXCL13 level (r = 0.901 / 0.458g, P < 0.05). Conclusion the serum IL-21,CXCL13 levels in healthy smokers, COPD stable and acute exacerbation patients were significantly increased, and the serum IL-21,CXCL13 levels were correlated with lung function and severity of disease in COPD stable patients. IL-21,CXCL13 may play an inflammatory role in the process of COPD.
【作者单位】： 第三军医大学新桥医院呼吸内科 全军呼吸内科研究所 全军呼吸病研究重点实验室;
【基金】：国家自然科学基金面上项目(81570051)~~
【分类号】：R563.9
，
本文编号：2428820
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