血清淀粉样蛋白A在慢性阻塞性肺疾病急性加重期中的应用价值

发布时间：2019-03-08 16:56

【摘要】：目的探讨血清淀粉样蛋白A(SAA)在慢性阻塞性肺疾病急性加重期(AECOPD)中的应用价值。方法随机入选符合入选标准的AECOPD患者70例,根据痰细菌培养是否阳性将AECOPD患者分为2组:感染组和加重组。慢性阻塞性肺疾病稳定期(SCOPD)患者35例设为对照组,收集入选者的一般资料,并完成肺功能、胸片、血常规、血清C反应蛋白(CRP)、SAA、血清白介素-6(IL-6)、血清降钙素原(PCT)检测,比较3组间SAA及相关指标的差异,分析SAA判别有无合并细菌感染的判别效率。结果 SAA在2组AECOPD患者中的水平均显著高于健康对照组,并且感染组显著高于加重组;SAA判别有无合并细菌感染的ROC曲线下面积为0.868 2,当SAA取界值72.10 mg/L时,灵敏度为94.29%,特异度为65.71%。结论 SAA在AECOPD患者中显著升高,在合并细菌感染时升高更显著,是AECOPD非特异性炎症及判别有无合并细菌感染的有效生物标志物之一。
[Abstract]:Objective to investigate the clinical value of serum amyloid protein A (SAA) in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 70 patients with AECOPD were randomly selected and divided into two groups according to whether sputum culture was positive or not: infection group and recombinant group. 35 patients with chronic obstructive pulmonary disease (SCOPD) in stable phase were set as control group. The general data of the subjects were collected and the pulmonary function, chest X-ray, blood routine and serum C-reactive protein (CRP), SAA, serum interleukin-6 (IL-6) were completed. Serum procalcitonin (PCT) was detected to compare the difference of SAA and related indexes among the three groups, and to analyze the discrimination efficiency of SAA in the identification of bacterial infection or not. Results the level of SAA in both groups was significantly higher than that in the healthy control group and the infection group was significantly higher than that in the control group. The area under the ROC curve of SAA was 0.868. When the SAA threshold was 72.10 mg/L, the sensitivity and specificity were 94.29% and 65.71%, respectively. Conclusion SAA is significantly increased in patients with AECOPD, especially in patients with bacterial infection. It is one of the effective biomarkers for non-specific inflammation of AECOPD and the identification of bacterial infection with or without bacterial infection.
【作者单位】：南方医科大学附属小榄医院呼吸内科;
【分类号】：R563.9

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