新疆维吾尔族和汉族肺结核患者白细胞介素-10及人肿瘤坏死因子-α表达水平的比较研究

发布时间：2019-03-11 09:18

【摘要】：目的探讨汉族、维吾尔族肺结核患者血清中人肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的含量以及民族间差异,并分析其与性别之间的关联。方法选取肺结核患者汉族132例,维吾尔族122例,用酶联免疫吸附双抗体夹心法测定患者血清中TNF-α、IL-10的含量。结果汉族和维吾尔族的肺结核患者血清中TNF-α分别为(21.72±7.18),(29.86±8.61)pg·mL~(-1);IL-10分别为(34.90±11.18),(41.65±18.11)pg·mL~(-1),差异均有统计学意义(均P0.05)。维吾尔族肺结核患者男性与女性血清IL-10分别为(44.93±18.56),(38.95±13.13)pg·mL~(-1),差异有统计学意义(P0.05);而TNF-α未见性别差异。汉族肺结核患者的上述因子均未见性别差异。结论新疆汉族肺结核患者血清TNF-α、IL-10含量和维吾尔族有明显差异,IL-10血清含量在维吾尔族不同性别的肺结核患者间也有差异。
[Abstract]:Objective to investigate the serum levels of tumor necrosis factor-伪 (TNF- 伪) and interleukin-10 (IL-10) in patients with pulmonary tuberculosis of Han nationality and Uygur nationality, and to analyze the relationship between serum TNF-伪, IL-10 and sex. Methods the serum levels of TNF- 伪 and IL-10 were determined by enzyme linked immunosorbent assay (Elisa) in 132 patients with pulmonary tuberculosis and 122 patients with Uygur nationality. Results the serum TNF- 伪 was (21.72 卤7.18), (29.86 卤8.61) pg 路mL ~ (- 1) in the patients with pulmonary tuberculosis of Han nationality and Uygur nationality, respectively. IL-10 was (34.90 卤11.18), () pg 路mL-1 (41.65 卤18.11) pg 路mL ~ (- 1), the difference was statistically significant (P 0.05). The serum IL-10 of Uighur patients with pulmonary tuberculosis was (44.93 卤18.56), () pg 路mL ~ (- 1) (38.95 卤13.13) pg 路mL ~ (- 1), but there was no significant difference in TNF- 伪 between males and females (P0.05). There was no gender difference in the above-mentioned factors in patients with pulmonary tuberculosis of Han nationality. Conclusion the serum levels of TNF- 伪, IL-10 and IL-10 in Xinjiang Han nationality patients with pulmonary tuberculosis are significantly different from those in Uygur nationality. There is also significant difference in serum IL-10 levels among patients with pulmonary tuberculosis in different sexes of Uighur nationality.
【作者单位】：石河子大学医学院第一附属医院药剂科;石河子大学医学院第一附属医院感染性疾病科;
【基金】：国家自然科学基金资助项目(81260079)
【分类号】：R521

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