恶性血液病患者侵袭性肺曲霉菌感染的治疗分析
发布时间：2019-03-16 11:06
【摘要】：目的研究恶性血液病患者侵袭性肺曲霉菌感染(IPA)抗真菌治疗效果及其影响因素,为临床资料提供参考依据。方法选择2008年1月-2013年4月收治的82例患者,根据不同的用药方案随机分为伏立康唑组28例、卡泊芬净组27例、联合组27例3组,比较各组患者的临床疗效、不良反应,并对疗效的影响因素,采用SAS9.0软件进行分析。结果共调查恶性血液病患者241例,其中IPA 82例,感染率为34.0%;联合组的抗真菌疗效显著优于伏立康唑组、卡泊芬净组(P0.05);单药与两药联合用药的不良反应差异无统计学意义;年龄≥50岁、接受造血干细胞移植(HSCT)、人类白细胞抗原(HLA)不匹配及既往IPA病史等均是IPA抗真菌治疗疗效的影响因素(P0.05)。结论伏立康唑与卡泊芬净联合用药的疗效优于单药,且不增加不良反应;年龄、HSCT、HLA不匹配及既往IPA病史等可影响疗效。
[Abstract]:Objective to study the effect of anti-fungal treatment of invasive pulmonary aspergillosis (IPA) in patients with malignant hematological disease and its influencing factors, so as to provide reference for clinical data. Methods from January 2008 to April 2013, 82 patients were randomly divided into three groups according to different drug regimen, 28 patients in valiconazole group, 27 patients in kapofenjing group and 27 patients in combination group. The clinical effects and adverse reactions of each group were compared. The influencing factors of curative effect were analyzed by SAS9.0 software. Results A total of 241cases of malignant hematological diseases were investigated, among which 82 cases were IPA, the infection rate was 34.0%, the antifungal effect of the combined group was significantly better than that of the Voliconazole group and the kapofenjing group (P0.05). There was no significant difference in adverse reactions between single and combined drugs. Age 鈮，
本文编号：2441202
[Abstract]:Objective to study the effect of anti-fungal treatment of invasive pulmonary aspergillosis (IPA) in patients with malignant hematological disease and its influencing factors, so as to provide reference for clinical data. Methods from January 2008 to April 2013, 82 patients were randomly divided into three groups according to different drug regimen, 28 patients in valiconazole group, 27 patients in kapofenjing group and 27 patients in combination group. The clinical effects and adverse reactions of each group were compared. The influencing factors of curative effect were analyzed by SAS9.0 software. Results A total of 241cases of malignant hematological diseases were investigated, among which 82 cases were IPA, the infection rate was 34.0%, the antifungal effect of the combined group was significantly better than that of the Voliconazole group and the kapofenjing group (P0.05). There was no significant difference in adverse reactions between single and combined drugs. Age 鈮，
本文编号：2441202
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