慢性阻塞性肺病继发骨质疏松患者血栓前状态

发布时间：2019-03-19 07:30

【摘要】：目的探讨慢性阻塞性肺病(COPD)继发骨质疏松(OP)的患者与血栓前状态分子标志物的关系。方法随机选取住院患者60例,其中COPD患者30例,COPD继发OP患者30例,采用流式细胞术、酶联免疫吸附(ELISA)方法等分别检测各组患者外周血中血小板功能〔(CD)41、CD62P、组织型纤溶酶原激活剂(t-PA)、组织型纤溶酶原激活剂抑制剂(PAI-1)、内皮素(ET)〕和凝血四项活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fib)的变化与特点。结果 COPD继发OP与单纯COPD患者CD41指标检测结果分别为72.58±2.13和75.24±2.07;CD62P检测结果分别为3.39±2.17和3.21±2.12,虽然二者之间均无统计学差异,但是其检测值均明显高于正常值。两组t-PA和PAI-1的检测结果无差异。两组ET的检测结果分别为123.76±41.22和104.68±41.94,差异显著(P0.05)。凝血四项指标的检测结果显示COPD继发OP与单纯COPD患者比较无统计学差异(P0.05)。结论 COPD患者以及COPD继发OP患者均存在不同程度的血栓前状态改变,表现在血管内皮细胞损伤、血小板活化、血液黏度增高、纤溶功能降低等方面,但两组之间比较血栓前状态差异性不大。
[Abstract]:Objective to investigate the relationship between (COPD) secondary osteoporosis (OP) and molecular markers of prethrombotic state in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty inpatients were randomly selected, including 30 patients with COPD and 30 patients with secondary OP of COPD. Platelet function (CD) 41 and CD62P were detected by flow cytometry and enzyme linked immunosorbent assay (ELISA) in peripheral blood of each group. Tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor (PAI-1), endothelin (ET) and coagulation activated partial thromboplastin time (APTT), prothrombin time (PT), Changes and characteristics of thrombin time (TT), fibrinogen (Fib). Results the levels of CD41 in patients with COPD secondary OP and simple COPD were 72.58 卤2.13,75.24 卤2.07, respectively. The results of CD62P were 3.39 卤2.17 and 3.21 卤2.12, respectively. Although there was no statistical difference between them, the results were significantly higher than the normal values. There was no difference in the results of t-PA and PAI-1 between the two groups. The results of ET detection in the two groups were 123.76 卤41.22 and 104.68 卤41.94, respectively, with significant difference (P0.05). The results of four indexes of coagulation showed that there was no significant difference in secondary OP between COPD and COPD patients (P0.05). Conclusion both COPD patients and secondary OP patients with COPD have different degrees of pre-thrombotic state changes, such as vascular endothelial cell injury, platelet activation, increased blood viscosity, decreased fibrinolytic function, and so on. But there was no significant difference in prethrombotic state between the two groups.
【作者单位】：新疆维吾尔自治区中医医院;
【基金】：新疆维吾尔自治区自然科学基金(面上项目)(No.2011211A090)
【分类号】：R563.9;R580

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