氟喹诺酮类药物抗结核研究的文献计量分析与系统评价

发布时间：2019-03-21 13:43

【摘要】：目的从文献计量学的角度统计分析氟喹诺酮类药物在抗结核研究领域的研究概况,为抗感染工作领域研究者提供参考。方法检索PubMed、Web of Science、Embase、中国知网等数据库,运用文献计量学分析方法,对纳入文献的年代、语言、期刊、作者及研究机构、文献类型、研究内容、被引频次等进行统计分析。结果文献共9 526篇,符合要求是3 109篇。文献量总体呈逐年上升趋势,文献中研究较多的药物是左氧氟沙星、环丙沙星、莫西沙星、氧氟沙星等。单篇文章被引频次最高的为181次,研究内容分析为氟喹诺酮类药物体外抗分枝杆菌活性、临床耐药情况、临床试验等。结论氟喹诺酮类药物作为二线抗结核治疗药物在对耐药、耐多药结核病的治疗中表现出良好的治疗效果,联合用药可能降低其耐药发生率,但是关于氟喹诺酮类药物与其他抗结核药物间的相互作用研究相对缺乏,今后可着重开展此方面研究。
[Abstract]:Objective to analyze the current research situation of fluoroquinolones in the field of anti-tuberculosis research from the perspective of bibliometrics so as to provide reference for researchers in the field of anti-infection. Methods the data base of PubMed,Web of Science,Embase, China knowledge Network was searched, and the date, language, journal, author and research institution, literature type and research content were analyzed by bibliometrics analysis, and the results were as follows: (1) the results were as follows: 1. The cited frequency order is statistically analyzed. Results A total of 9 526 articles were published, which met the requirements of 3 109 articles. The literature volume is increasing year by year. The drugs studied in the literature are levofloxacin, ciprofloxacin, floxacin and so on. The highest frequency of single article was 181 times. The contents of the study were as follows: the activity of fluoroquinolones against Mycobacterium in vitro, clinical drug resistance, clinical trials and so on. Conclusion as a second-line anti-tuberculosis drug, fluoroquinolones have a good therapeutic effect in the treatment of drug-resistant and multi-drug-resistant tuberculosis, and combined use of fluoroquinolones may reduce the incidence of drug resistance. However, there is relatively little research on the interaction between fluoroquinolones and other anti-tuberculosis drugs, which can be focused on in the future.
【作者单位】：中国人民解放军总医院药品保障中心;中国人民解放军总医院呼吸科;中国人民解放军总医院药物临床研究中心;
【基金】：十二五国家重大科技专项(2012ZX09303004-002)
【分类号】：R521

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