气道分泌物廓清技术集束化管理在氧气驱动雾化吸入疗法中的应用

发布时间：2019-04-21 11:11

【摘要】：目的:评价在氧气驱动雾化吸入治疗时进行气道分泌物廓清技术集束化管理的有效性及安全性。方法:选取慢性阻塞性肺病急性加重期患者280例,按随机数字表法分为A、B、C、D组,各70例,A、B组应用复方异丙托溴铵2 ml加生理盐水5 ml,10min/次,每日2次,6 L/min氧气驱动雾化吸入治疗7 d;C、D组应用盐酸氨溴索注射液15 mg加生理盐水5 ml,10 min/次,每日2次,6 L/min氧气驱动雾化吸入治疗7天。A组和C组为治疗组,B组和D组为对照组。两治疗组患者在吸入相应药物治疗的同时进行气道分泌物廓清技术集束化管理,两对照组患者在吸入相应药物治疗的同时进行单一的有效咳嗽指导。结果:治疗组患者咳痰量增多、动脉血氧分压(Pa O2)提高、动脉血二氧化碳分压(Pa CO2)下降、住院时间缩短,与对照组比较差异有统计学意义(P0.05)。结论:在氧气驱动雾化吸入疗法中进行气道分泌物廓清技术集束化管理是慢性阻塞性肺疾病治疗中一种简便、安全、有效的方法。
[Abstract]:Objective: to evaluate the effectiveness and safety of collection management of airway secretion clearance in oxygen-driven atomization inhalation therapy. Methods: 280 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) were randomly divided into A, B, C, D groups (70 cases). Group B was treated with compound isopropylobromide 2 ml plus saline for 5 ml,10min/ twice a day, and the patients in group A were divided into three groups: group A (n = 70), group B (n = 70) and group D (n = 70). 6 L/min oxygen driven atomization inhalation for 7 days; Group C, D were treated with ambroxol hydrochloride 15 mg plus saline for 5 ml,10 min/ twice a day for 7 days, 6 L/min oxygen driven atomization inhalation for 7 days, group A and C were treated with treatment group, group B and D were treated with control group. The patients in the two treatment groups received the collection management of airway secretion clearance technology while inhaling the corresponding drugs, and the patients in the two control groups received a single effective cough instruction while inhaling the corresponding drugs. Results: in the treatment group, expectoration volume increased, arterial blood oxygen partial pressure (Pa-O _ 2) increased, arterial blood carbon dioxide partial pressure (Pa CO2) decreased, hospital stay shortened, and there was a significant difference compared with the control group (P0.05). Conclusion: the collection management of airway secretion clearance in oxygen-driven atomization inhalation therapy is a simple, safe and effective method in the treatment of chronic obstructive pulmonary disease.
【作者单位】：辽宁医学院附属第一医院;
【分类号】：R563.9

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