血清HDL-C、TNF-α检测在COPD急性加重期治疗中的应用

发布时间：2019-04-24 17:11

【摘要】：目的探讨血清HDL-C、TNF-α水平检测在慢性阻塞性肺病(COPD)患者急性加重期治疗中的价值。方法选择急性加重期COPD(AECOPD)患者157例(AECOPD组)、稳定期COPD患者75例(稳定期COPD组)、健康体检者72例(对照组),检测各组白细胞计数、中性粒细胞比例、hs-CRP、PCT、HDL-C、TNF-α水平以及肺功能。受试者工作特征(ROC)曲线评估HDL-C、TNF-α水平早期识别AECOPD的价值。结果 AECOPD组与对照组、稳定期COPD组比较血清HDL-C水平治疗前降低(P0.01)、治疗后较治疗前增高(P0.05),血清TNF-α水平治疗前增高(P0.01)、治疗后较治疗前降低(P0.05)。ROC曲线显示,血清HDL-C、TNF-α水平判断AECOPD的曲线下面积分别为0.893、0.857,截断值分别为0.92 mmol/L、23.56 ng/m L,敏感度分别为91.08%、87.90%,特异度分别为89.80%、85.03%。结论血清HDL-C、TNF-α水平是早期识别AECOPD和评估其治疗效果的有效指标。
[Abstract]:Objective to investigate the value of serum HDL-C,TNF- 伪 level in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 157 patients with acute exacerbation COPD (AECOPD) (AECOPD group), 75 patients with stable COPD (stable COPD group) and 72 healthy controls (control group) were selected. Leukocyte count, neutrophil ratio and hs-CRP,PCT, were measured in each group. HDL-C,TNF- 伪 level and pulmonary function. The (ROC) curve was used to evaluate the value of early identification of AECOPD at HDL-C,TNF- 伪 level. Results compared with control group and stable COPD group, serum HDL-C level in AECOPD group decreased before treatment (P0.01), increased after treatment (P0.05), and serum TNF- 伪 level increased before treatment (P0.01). The ROC curve showed that the area under the curve of serum HDL-C,TNF- 伪 was 0.893, 0.857, and the cut-off value was 0.92 mmol/L,23.56 ng/m / L, respectively, and the area under the curve was 0.893, 0.857 and 0.92 mmol/L,23.56 ng/m / L, respectively. The sensitivity, specificity and specificity were 91.08%, 87.90%, 89.80% and 85.03%, respectively. Conclusion Serum HDL-C,TNF- 伪 level is an effective index for early identification of AECOPD and evaluation of its therapeutic effect.
【作者单位】：南京医科大学附属苏州市立医院本部;邹平县明集中心卫生院;
【分类号】：R563.9

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