MSCT肺容积与PFT检测指标在慢性阻塞性肺气肿早期诊断中的价值研究
发布时间：2019-05-09 11:20
【摘要】：目的：探讨多层螺旋CT（Multislice spiral computerized tomography，MSCT）肺容积测定与肺功能测定（Pulmonary function test，PFT）在慢性阻塞性肺气肿早期数据相关性，评估二者在慢性阻塞性肺气肿早期的诊断价值。 方法：临床搜集具有明确吸烟病史并慢性支气管炎患者67例，根据目前临床诊断慢性阻塞性肺气肿主要依据PFT测定指标残总比值（RV/TLC）大于40%即肺气肿组31例，小于40%者为不能通过PFT测定诊断慢性阻塞性肺气肿组36例，每一位患者于PFT测定结束3天内行MSCT肺容积测定。采用SPSS17.0统计学软件进行数据处理，计量资料用（x s）表示，组间数据比较采用独立样本t检验，MSCT肺容积指标深呼气末容积（Vex）、深吸气末容积（Vin）、深吸气末与深呼气末容积差值（Vin-Vex）、深呼气末容积与深吸气末比值（Vex/Vin）分别与PFT测定指标残气量（RV）、肺总量（TLC）、用力肺活量（FVC）、残总比值（RV/TLC）应用相关性分析；MSCT肺容积指标Vex/Vin与PFT测定指标RV/TLC按RV/TLC大于40%为肺气肿诊断标准，绘制ROC曲线评估其诊断价值。 结果：两组数据比较其差异具有统计学意义（P＜0.05），MSCT肺容积指标Vex与PFT测定指标RV存在显著相关性（r=0.927），Vin与TLC存在显著相关性（r=0.831），Vex/Vin与RV/TLC存在中等程度相关性（r=0.664），ROC曲线显示PFT测定指标RV/TLC线下面积为0.712，MSCT肺容积指标Vex/Vin线下面积为0.826，诊断慢性阻塞性肺气肿早期优于PFT测定指标RV/TLC。 结论：MSCT肺容积测定指标与PFT测定指标具有相关性能够反应肺功能变化，MSCT肺容积指标Vex/Vin较PFT测定指标RV/TLC在反应慢性阻塞性肺气肿早期肺功能变化具有更高的准确性，因此对诊断慢性阻塞性肺气肿早期具有临床预测意义，是较为敏感的指标。目前临床上缺乏MSCT相关诊断标准，因此有必要更为深入研究并制定更适合MSCT肺容积慢性阻塞性肺气肿早期诊断标准，以利于更及时准确发现和诊断慢性阻塞性肺气肿早期患者。
[Abstract]:Objective: to investigate the correlation between multi-slice spiral CT (Multislice spiral computerized tomography,MSCT (lung volume measurement) and pulmonary function measurement (Pulmonary function test,PFT) in the early stage of chronic obstructive emphysema (COPD), and to evaluate their diagnostic value in the early stage of chronic obstructive emphysema (COPD). Methods: 67 patients with a definite history of smoking and chronic bronchitis were collected. According to the current clinical diagnosis of chronic obstructive emphysema, the residual total ratio (RV/TLC) measured by PFT was more than 40%, that is, 31 patients in emphysema group. Thirty-six patients with chronic obstructive emphysema (COPD) could not be diagnosed by PFT assay. MSCT pulmonary volume was measured within 3 days after PFT test in each of the 36 patients with chronic obstructive emphysema (COPD). SPSS17.0 statistical software was used to process the data, (x s) was used to express the measurement data, and independent sample t test was used to compare the data between groups. MSCT lung volume index, deep end expiratory volume (Vex), deep inspiratory end volume (Vin), were used to compare the data between groups. The difference between deep end-inspiratory volume and deep end-breath volume (Vin-Vex), the ratio of deep end-inspiratory volume to deep end-inspiratory volume (Vex/Vin) and PFT were measured by PFT, respectively. The total lung volume of (RV), was determined by (TLC), forced vital capacity (FVC),). The residual total ratio (RV/TLC) was analyzed by correlation analysis. According to the diagnostic criteria of emphysema, MSCT pulmonary volume index (Vex/Vin) and PFT index (RV/TLC) were measured according to RV/TLC > 40%. ROC curve was drawn to evaluate the diagnostic value of emphysema. Results: there was significant difference between the two groups (P < 0.05). There was a significant correlation between the lung volume index Vex and the PFT index RV (r 鈮，
本文编号：2472730
[Abstract]:Objective: to investigate the correlation between multi-slice spiral CT (Multislice spiral computerized tomography,MSCT (lung volume measurement) and pulmonary function measurement (Pulmonary function test,PFT) in the early stage of chronic obstructive emphysema (COPD), and to evaluate their diagnostic value in the early stage of chronic obstructive emphysema (COPD). Methods: 67 patients with a definite history of smoking and chronic bronchitis were collected. According to the current clinical diagnosis of chronic obstructive emphysema, the residual total ratio (RV/TLC) measured by PFT was more than 40%, that is, 31 patients in emphysema group. Thirty-six patients with chronic obstructive emphysema (COPD) could not be diagnosed by PFT assay. MSCT pulmonary volume was measured within 3 days after PFT test in each of the 36 patients with chronic obstructive emphysema (COPD). SPSS17.0 statistical software was used to process the data, (x s) was used to express the measurement data, and independent sample t test was used to compare the data between groups. MSCT lung volume index, deep end expiratory volume (Vex), deep inspiratory end volume (Vin), were used to compare the data between groups. The difference between deep end-inspiratory volume and deep end-breath volume (Vin-Vex), the ratio of deep end-inspiratory volume to deep end-inspiratory volume (Vex/Vin) and PFT were measured by PFT, respectively. The total lung volume of (RV), was determined by (TLC), forced vital capacity (FVC),). The residual total ratio (RV/TLC) was analyzed by correlation analysis. According to the diagnostic criteria of emphysema, MSCT pulmonary volume index (Vex/Vin) and PFT index (RV/TLC) were measured according to RV/TLC > 40%. ROC curve was drawn to evaluate the diagnostic value of emphysema. Results: there was significant difference between the two groups (P < 0.05). There was a significant correlation between the lung volume index Vex and the PFT index RV (r 鈮，
本文编号：2472730
本文链接：https://www.wllwen.com/yixuelunwen/huxijib/2472730.html
最近更新
教材专著
