多沙普仑联合无创通气治疗慢性阻塞性肺疾病肺性脑病的疗效

发布时间：2019-05-16 21:05

【摘要】：目的探讨多沙普仑联合无创通气治疗慢性阻塞性肺疾病(COPD)肺性脑病的临床价值。方法选择80例患者,分为两组各40例,对照组应用无创通气,观察组在对照组基础上使用多沙普仑,治疗后12 h,比较两组患者血气分析结果,呼吸频率及潮气量变化情况,统计两组治疗转归。结果治疗后12 h,观察组pH高于对照组,血氧饱和度(SpO2)高于对照组,二氧化碳分压(PCO2)低于对照组,氧分压(PO2)高于对照组,呼吸频率快于对照组,潮气量小于对照组,使用无创呼吸机后好转脱机高于对照组,临床死亡率低于对照组(均P0.05)。结论对于COPD出现肺性脑病患者,使用多沙普仑联合无创通气,有效避免了有创通气引起的并发症,能更好地改善患者缺氧及二氧化碳潴留,提高患者预后。
[Abstract]:Objective to evaluate the clinical value of doxapron combined with noninvasive ventilation in the treatment of chronic obstructive pulmonary disease (COPD) with pulmonary encephalopathy. Methods 80 patients were divided into two groups: control group (n = 40) and control group (n = 40). The observation group was treated with doxapron on the basis of control group. 12 hours after treatment, the results of blood gas analysis, respiratory frequency and tidal volume were compared between the two groups. The outcome of treatment in the two groups was counted. Results 12 hours after treatment, pH in the observation group was higher than that in the control group, blood oxygen saturation (SpO2) was higher than that in the control group, partial pressure of carbon dioxide (PCO2) was lower than that in the control group, partial pressure of oxygen (PO2) was higher than that in the control group, and respiratory frequency was faster than that in the control group. The tidal volume was smaller than that of the control group, and the clinical mortality of the control group was lower than that of the control group (P 0.05). Conclusion Doxapron combined with noninvasive ventilation can effectively avoid the complications caused by invasive ventilation, improve hypoxia and carbon dioxide retention and improve the prognosis of patients with pulmonary encephalopathy in COPD.
【作者单位】：苍南县人民医院;
【分类号】：R563.9;R747.9

【相似文献】