益气涤痰通腑汤辅助治疗慢性阻塞性肺疾病合并呼吸衰竭患者100例临床观察

发布时间：2019-05-21 23:04

【摘要】：目的观察益气涤痰通腑汤辅助治疗脱机困难的慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的临床疗效。方法将195例脱机困难的COPD合并呼吸衰竭患者随机分为治疗组100例和对照组95例,两组均采用机械通气、解痉化痰、导泻、抗感染、对症支持治疗,治疗组在此基础上鼻胃管灌服益气涤痰通腑汤,每日2次。治疗前和治疗第6、12天观察两组患者浅快呼吸指数(RSBI)、自主潮气量(sTv)及最大吸气负压(MIP)。治疗第6、12天记录两组患者脱机成功例数,计算脱机成功率,观察不良反应。结果治疗组治疗第6、12天脱机成功率分别为40.00%、78.00%,明显高于对照组的21.05%、43.16%。治疗组治疗第6、12天RSBI、sTv、MIP均较治疗前明显改善(P0.05或P0.01);对照组治疗第6、12天RSBI较治疗前明显降低,治疗第12天sTv、MIP均较治疗前明显升高(P0.05或P0.01)。治疗组治疗第6、12天RSBI、sTv、MIP均较对照组明显改善(P0.05或P0.01)。结论益气涤痰通腑汤辅助治疗脱机困难的COPD合并呼吸衰竭患者,能明显提高脱机成功率,改善通气功能。
[Abstract]:Objective to observe the clinical effect of Yiqi Ditan Tongfu decoction in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods 195 patients with COPD complicated with respiratory failure were randomly divided into treatment group (n = 100) and control group (n = 95). Both groups were treated with mechanical ventilation, antispasmodic phlegm, diarrhea, anti-infection and symptomatic support. On this basis, the treatment group was treated with Yiqi Ditan Tongfu decoction, twice a day. The spontaneous tidal volume (sTv) and maximum inspiratory negative pressure (MIP). Of shallow fast respiratory index (RSBI), and maximum inspiratory negative pressure were observed before treatment and on the 6th and 12th day of treatment. On the 6th and 12th day of treatment, the successful cases of weaning were recorded, the success rate of weaning was calculated, and the adverse reactions were observed. Results on the 6th and 12th day of treatment, the success rate of weaning in the treatment group was 40.00% and 78.00% respectively, which was significantly higher than that in the control group (21.05% and 43.16%). On the 6th and 12th day of treatment, the RSBI,sTv,MIP of the treatment group was significantly improved compared with that before treatment (P05 or P01), while that of the control group on the 6th and 12th day of treatment was significantly lower than that before treatment, and the sTv,MIP of the 12th day of treatment was significantly higher than that before treatment (P05 or P01). On the 6th and 12th day of treatment, RSBI,sTv,MIP in the treatment group was significantly better than that in the control group (P 0.05 or P 0.01). Conclusion Yiqi Ditan Tongfu decoction can significantly improve the success rate and ventilation function of COPD patients with respiratory failure who are difficult to wean.
【作者单位】：开封市第二人民医院;
【基金】：开封市科技发展计划资助项目(100343)
【分类号】：R563.9;R563.8

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