慢性阻塞性肺疾病急性加重与呼吸道常见病原体感染的相关研究

发布时间：2019-05-22 23:42

【摘要】：目的：回顾性分析呼吸道常见病原体感染与慢性阻塞性肺疾病急性加重期（AECOPD）的关系及对血气分析的影响。方法：对2011年2月至2013年2月我院呼吸科收住的200例AECOPD患者的血清标本应用呼吸道联检试剂(间接免疫荧光法)同时检测9项主要病原体的IgM抗体，包括甲型流感病毒(IFA)、乙型流感病毒(IFB)、嗜肺军团菌(LP)、肺炎衣原体(CP)、肺炎支原体(MP)、呼吸道合胞病毒(RSV)、腺病毒(ADV)、副流感病毒1、2和3型(PIVS)和Q热立克次体(COX),同时根据血气分析将200名患者分成呼吸衰竭组（54例）和非呼吸衰竭组（146例），根据患者患者临床表现、体征及生化指标等，分析每种病原体的阳性率及两组在呼吸道感染的阳性率。结果：AECOPD患者中，感染阳性者62例，总阳性率为31%（62/200），各病原体中病毒的感染率较高，其中IFB占13.5%（27/200），RSV占4%（8/200）, IFA占3.5%(7/200)，ADV占3%（6/200），PIVS占2%（4/200），在非典型病原体中，MP占7.5%（15/200），，LP占5%（10/200）, COX占0.5%（1/200）；合并呼吸衰竭是阳性率较非合并阳性率较高（P0.05）；同时合并2种病原体感染有9例，占阳性病例的14.5%，合并3种病原体的感染有4例，占阳性病例的2%。结论：呼吸道病原体感染是AECOPD的重要诱因，其中呼吸道病毒感染是最常见的病原体，AECOPD患者合并呼吸衰竭时病原体的阳性率较非合并呼吸衰竭高，同时AECOPD患者易有多重病原体的混合感染。
[Abstract]:Objective: to analyze the relationship between common pathogen infection of respiratory tract and (AECOPD) in acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on blood gas analysis. Methods: from February 2011 to February 2013, the serum samples of 200 patients with AECOPD in respiratory department of our hospital were detected by respiratory tract test reagent (indirect immunofluorescence method) to detect IgM antibodies against 9 major pathogens, including influenza A virus (IFA),. Type B influenza virus (IFB), Legionella pneumophils (LP), chlamydia pneumoniae (CP), mycoplasma pneumoniae (MP), respiratory syncytial virus (RSV), adenoviruses (ADV), Two hundred patients were divided into respiratory failure group (54 cases) and non-respiratory failure group (146cases) according to blood gas analysis. According to the clinical manifestations of parainfluenza virus 1, type 2 and type 3 (PIVS) and Q Rickettsia (COX), the patients were divided into respiratory failure group (n = 54) and non-respiratory failure group (n = 146) according to the clinical manifestations of the patients. The positive rate of each pathogen and the positive rate of respiratory tract infection in the two groups were analyzed. Results: among the patients with AECOPD, 62 cases were positive, the total positive rate was 31% (62 鈮

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