隐源性机化性肺炎:32例临床、影像学资料分析
发布时间:2019-05-28 11:43
【摘要】:目的:分析32例隐源性机化性肺炎(COP)的临床和影像学特征并复习有关文献,以提高对该病的诊治水平。方法:搜集整理2012年12月~2016年12月病理确诊的32例COP病人的一般资料、实验室检查、肺功能和动脉血气分析、临床表现及影像学特征,并对这些数据资料进行回顾性总结分析。结果:32例COP患者中,男性多于女性(21/11),年龄主要分布于46~75岁(平均年龄60.4±14.5岁),其中吸烟者占12.5%;临床表现以咳痰(53.1%)最常见,痰量较少,其余症状依次为呼吸困难(25.0%)、胸痛(25.0%)、干咳(21.9%)、痰中带血(21.9%)、体重减轻(15.6%)、发热(12.5%)、盗汗(12.5%)及乏力(9.4%);实验室检查:血常规白细胞水平多为正常(87.5%),但绝大部分患者呈现血沉增快(94.1%)及C反应蛋白(86.7%)增高;半数以上患者存在轻度的限制性通气功能障碍;部分患者有轻度低氧血症(45.5%);胸部CT表现以磨玻璃影最常见(22例,68.8%)、其次为斑片状实变(13例,40.6%)或软组织肿块影(10例,31.3%),少数表现为结节、条索状病灶、空洞、蜂窝状病变及胸腔积液。结节和肿块型隐源性机化性肺炎(NMCOP)共17例,其一般情况及实验室检查:男性多于女性(11/6),年龄主要分布于47~66岁(平均年龄56.3±9.6岁),吸烟占28.6%;临床症状依次为咳嗽咳痰(70.6%)、胸痛(23.5%)、痰中带血(23.5%);仅1例(5.9%)CEA升高,其他肿瘤标记物均为阴性,3例(17.6%)D-二聚体升高;胸部CT表现:不规则形病灶11例(64.7%),圆形或者类圆形病灶6例(35.3%);边缘模糊12例(70.6%),边缘清晰5例(29.4%);浅分叶5例(29.4%),深分叶2例(11.8%);长毛刺2例(11.8%),短毛刺1例(5.9%);血管集束征2例(11.8%),棘突征6例(35.3%),在6例累及胸膜者中,仅1例(16.7%,1/6)有脂肪间隙。结论:COP临床表现、实验室检查及影像学多无明显特异性,确诊仍需依赖病理学诊断,对以磨玻璃样影和实变影或结节和肿块样表现的患者,必须结合患者的临床资料和胸部影像学表现进行综合分析,及时行肺组织病理活检,有助于排除其它疾病尤其肺癌,减少误诊。
[Abstract]:Objective: to analyze the clinical and imaging features of 32 cases of cryptogenic organic pneumonia (COP) and review the relevant literature in order to improve the diagnosis and treatment of the disease. Methods: the general data, laboratory examination, pulmonary function and arterial blood gas analysis, clinical manifestations and imaging features of 32 patients with COP diagnosed pathologically from December 2012 to December 2016 were collected and analyzed. Results: among the 32 patients with COP, there were more males than females (21 鈮,
本文编号:2487020
[Abstract]:Objective: to analyze the clinical and imaging features of 32 cases of cryptogenic organic pneumonia (COP) and review the relevant literature in order to improve the diagnosis and treatment of the disease. Methods: the general data, laboratory examination, pulmonary function and arterial blood gas analysis, clinical manifestations and imaging features of 32 patients with COP diagnosed pathologically from December 2012 to December 2016 were collected and analyzed. Results: among the 32 patients with COP, there were more males than females (21 鈮,
本文编号:2487020
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